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Tbio
CLDN14
Claudin-14

Protein Summary
Description
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated w ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342108
  • ENSP00000339292
  • ENSG00000159261
  • ENST00000399135
  • ENSP00000382087
  • ENST00000399136
  • ENSP00000382088
  • ENST00000399137
  • ENSP00000382090
  • ENST00000399139
  • ENSP00000382092

Symbol
  • DFNB29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.7
transcription factor
0.67
cell type or tissue
0.66
kinase perturbation
0.66
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.92   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.92   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.2
98.1
heel bone mineral density
2
2
2
92.7
hematocrit
4
1
4
86.3
hemoglobin measurement
3
1
3
83.3
red blood cell density measurement
1
1
1
81.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
98.1
heel bone mineral density
2
92.7
hematocrit
4
86.3
hemoglobin measurement
3
83.3
red blood cell density measurement
1
81.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
claudin 14
VGNC:1155
470085
Macaque
claudin 14
695087
Mouse
MGI:1860425
56173
Rat
RGD:1309165
304073
Dog
claudin 14
VGNC:39311
487751
Species
Name
OMA
EggNOG
Inparanoid
Chimp
claudin 14
Macaque
claudin 14
Mouse
Rat
Dog
claudin 14
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95500-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (41)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (74)
1 – 10 of 74
CLDN12
Tbio
Novelty: 0.04404633
Score: 0.951
Data Source: STRINGDB
CLDN16
Tbio
Novelty: 0.0092505
Score: 0.935
Data Source: STRINGDB
CLDN11
Tbio
Novelty: 0.00275436
Score: 0.922
Data Source: STRINGDB
CLDN23
Tbio
Novelty: 0.12349944
Score: 0.918
Data Source: STRINGDB
CLDN10
Tbio
Novelty: 0.02175843
Score: 0.912
Data Source: STRINGDB
CLDN8
Tbio
Novelty: 0.02218455
Score: 0.909
Data Source: STRINGDB
CLDN18
Tbio
Novelty: 0.01299528
Score: 0.909
Data Source: STRINGDB
CLDN17
Tbio
Novelty: 0.23348754
Score: 0.909
Data Source: STRINGDB
CLDN15
Tbio
Novelty: 0.02763602
Score: 0.909
Data Source: STRINGDB
CLDN9
Tbio
Novelty: 0.06435094
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score  54.92

PubMed score by year
PubTator Score  36.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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