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Tbio
COL25A1
Collagen alpha-1(XXV) chain

Protein Summary
Description
Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399126
  • ENSP00000382077
  • ENSG00000188517
  • ENST00000399132
  • ENSP00000382083

Symbol
  • AMY
  • CLAC
  • CLACP
  • CFEOM5
  • CLAC-P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
histone modification site profile
0.77
trait
0.75
phenotype
0.72
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.45   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.45   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

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Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen degradation
Reactome
Collagen formation
Reactome
Degradation of the extracellular matrix
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen degradation
Collagen formation
Degradation of the extracellular matrix
Protein-Protein Interactions (86)
1 – 10 of 86
PLOD1
Tbio
Family: Enzyme
Novelty: 0.00905345
p_int: 0.990448833
p_ni: 5.55e-7
p_wrong: 0.009550612
Score: 0.921
Data Source: BioPlex,STRINGDB
FURIN
Tchem
Family: Enzyme
Novelty: 0.00055079
Score: 0.929
Data Source: STRINGDB
COL26A1
Tbio
Novelty: 0.07322658
Score: 0.928
Data Source: STRINGDB
COL21A1
Tbio
Novelty: 0.1583142
Score: 0.921
Data Source: STRINGDB
COL3A1
Tbio
Novelty: 0.00197327
Score: 0.919
Data Source: STRINGDB
COL16A1
Tbio
Novelty: 0.11147945
Score: 0.918
Data Source: STRINGDB
COL4A5
Tbio
Novelty: 0.00283701
Score: 0.918
Data Source: STRINGDB
COL5A2
Tbio
Novelty: 0.01352973
Score: 0.918
Data Source: STRINGDB
COL4A1
Tbio
Novelty: 0.00358049
Score: 0.918
Data Source: STRINGDB
COL13A1
Tbio
Novelty: 0.040988
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.45

PubMed score by year
PubTator Score  22.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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