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Tbio
TTC3
E3 ubiquitin-protein ligase TTC3

Protein Classes
Protein Summary
Description
E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354749
  • ENSP00000346791
  • ENSG00000182670
  • ENST00000355666
  • ENSP00000347889
  • ENST00000399017
  • ENSP00000381981

Symbol
  • DCRR1
  • RNF105
  • TPRD
  • DCRR1
  • RNF105
  • TPRDIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
1
virus perturbation
0.92
disease perturbation
0.9
histone modification site profile
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.35   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.35   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eye color
1
1
1
63.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eye color
1
63.9
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (70)
1 – 10 of 70
EIF2B5
Tbio
Novelty: 0.0102209
p_int: 0.999947724
p_ni: 0.000051271
p_wrong: 0.000001005
Data Source: BioPlex
DYNC2LI1
Tbio
Novelty: 0.05087433
p_int: 0.948369713
p_ni: 0.000020943
p_wrong: 0.051609344
Score: 0.517
Data Source: BioPlex,STRINGDB
CA3
Tclin
Family: Enzyme
Novelty: 0.00137568
Score: 0.794
Data Source: STRINGDB
CCT3
Tbio
Novelty: 0.01642521
Score: 0.733
Data Source: STRINGDB
GGACT
Tbio
Family: Enzyme
Novelty: 0.20580326
Score: 0.73
Data Source: STRINGDB
GGT1
Tbio
Family: Enzyme
Novelty: 0.00252374
Score: 0.677
Data Source: STRINGDB
GGTLC3
Tdark
Family: Enzyme
Novelty: 0.00416359
Score: 0.677
Data Source: STRINGDB
GGT2
Tbio
Family: Enzyme
Novelty: 0.00399971
Score: 0.677
Data Source: STRINGDB
SLC18A1
Tchem
Family: Transporter
Novelty: 0.01135292
Score: 0.658
Data Source: STRINGDB
DSCR3
Tbio
Novelty: 0.05414856
Score: 0.657
Data Source: STRINGDB
Publication Statistics
PubMed Score  35.35

PubMed score by year
PubTator Score  11.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer