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Tdark
DEFB113
Beta-defensin 113

Protein Summary
Description
Has antibacterial activity. Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398718
  • ENSP00000381703
  • ENSG00000214642

Symbol
  • DEFB13
  • DEFB-13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.44
biological term
0.33
pathway
0.32
disease
0.24
tissue
0.24


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.14   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 6   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.14   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defensin beta 113
VGNC:2741
740626
Macaque
defensin beta 113 [Source:HGNC Symbol;Acc:HGNC:18094]
Mouse
MGI:3648148
654460
Rat
RGD:1559758
641655
Dog
defensin beta 113 [Source:HGNC Symbol;Acc:HGNC:18094]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defensin beta 113
Macaque
defensin beta 113 [Source:HGNC Symbol;Acc:HGNC:18094]
Mouse
Rat
Dog
defensin beta 113 [Source:HGNC Symbol;Acc:HGNC:18094]
Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (35)
1 – 10 of 35
DEFB110
Tdark
Novelty: 0.49548192
Score: 0.983
Data Source: STRINGDB
DEFB121
Tdark
Novelty: 2.72797456
Score: 0.972
Data Source: STRINGDB
DEFB129
Tdark
Novelty: 0.26809608
Score: 0.972
Data Source: STRINGDB
DEFB124
Tbio
Novelty: 1.65330827
Score: 0.955
Data Source: STRINGDB
DEFB135
Tdark
Novelty: 2.04107063
Score: 0.946
Data Source: STRINGDB
DEFB128
Tbio
Novelty: 0.30093411
Score: 0.946
Data Source: STRINGDB
DEFB126
Tbio
Novelty: 0.05538355
Score: 0.943
Data Source: STRINGDB
DEFB1
Tbio
Novelty: 0.00144458
Score: 0.936
Data Source: STRINGDB
DEFB136
Tdark
Score: 0.934
Data Source: STRINGDB
DEFA3
Tbio
Novelty: 0.04840173
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.14

PubMed score by year
PubTator Score  0.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer