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Tbio
PAX1
Paired box protein Pax-1

Protein Summary
Description
This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity). This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene. Mutations in this gene are also associated with vertebral malformations. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398485
  • ENSP00000381499
  • ENSG00000125813
  • ENST00000444366
  • ENSP00000410355

Symbol
  • HUP48
  • OFC2
  • HUP48
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.82
biological process
0.8
virus perturbation
0.72
PubMedID
0.6
cell type or tissue
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.32   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.32   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
26.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
26.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
paired box 1
VGNC:6225
458132
Macaque
paired box 1
706866
Mouse
MGI:97485
18503
Dog
paired box 1
VGNC:44275
485743
Cow
paired box 1 [Source:HGNC Symbol;Acc:HGNC:8615]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
paired box 1
Macaque
paired box 1
Mouse
Dog
paired box 1
Cow
paired box 1 [Source:HGNC Symbol;Acc:HGNC:8615]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P15863-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (74)
1 – 10 of 74
MEOX1
Tbio
Family: TF
Novelty: 0.02978667
Score: 0.773
Data Source: STRINGDB
FOXN1
Tbio
Family: TF
Novelty: 0.00338433
Score: 0.759
Data Source: STRINGDB
HOXA3
Tbio
Family: TF
Novelty: 0.01407069
Score: 0.756
Data Source: STRINGDB
ZNF582
Tbio
Family: TF
Novelty: 0.09450649
Score: 0.71
Data Source: STRINGDB
SHH
Tchem
Novelty: 0.00028347
Score: 0.706
Data Source: STRINGDB
TCF15
Tbio
Family: TF
Novelty: 0.00110253
Score: 0.681
Data Source: STRINGDB
UNK
Tbio
Novelty: 0.01101154
Score: 0.659
Data Source: STRINGDB
SEMA5B
Tbio
Novelty: 0.0151789
Score: 0.647
Data Source: STRINGDB
UNCX
Tbio
Family: TF
Novelty: 0.05605716
Score: 0.642
Data Source: STRINGDB
NOG
Tbio
Novelty: 0.0010373
Score: 0.637
Data Source: STRINGDB
Publication Statistics
PubMed Score  163.32

PubMed score by year
PubTator Score  59.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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