You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TCF4
Transcription factor 4

Protein Summary
Description
Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354452
  • ENSP00000346440
  • ENSG00000196628
  • ENST00000356073
  • ENSP00000348374
  • ENST00000457482
  • ENSP00000409447
  • ENST00000537578
  • ENSP00000440731
  • ENST00000537856
  • ENSP00000439827
  • ENST00000540999
  • ENSP00000445202
  • ENST00000543082
  • ENSP00000439656
  • ENST00000544241
  • ENSP00000441562
  • ENST00000561831
  • ENSP00000457765
  • ENST00000561992
  • ENSP00000455179
  • ENST00000564228
  • ENSP00000455261
  • ENST00000564999
  • ENSP00000457649
  • ENST00000565018
  • ENSP00000455984
  • ENST00000566279
  • ENSP00000456125
  • ENST00000566286
  • ENSP00000455418
  • ENST00000567880
  • ENSP00000454366
  • ENST00000568673
  • ENSP00000455135
  • ENST00000570177
  • ENSP00000454647
  • ENST00000570287
  • ENSP00000455763
  • ENST00000616053
  • ENSP00000478549
  • ENST00000626584
  • ENSP00000486072
  • ENST00000629387
  • ENSP00000486670
  • ENST00000636400
  • ENSP00000490006

Symbol
  • BHLHB19
  • ITF2
  • SEF2
  • E2-2
  • ITF2
  • PTHS
  • SEF2
  • FECD3
  • ITF-2
  • SEF-2
  • TCF-4
  • SEF2-1
  • SEF2-1A
  • SEF2-1B
  • SEF2-1D
  • bHLHb19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
kinase perturbation
0.98
disease perturbation
0.97
transcription factor perturbation
0.97
small molecule perturbation
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 410.9   (req: < 5)
Gene RIFs: 113   (req: <= 3)
Antibodies: 349   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 410.9   (req: >= 5)
Gene RIFs: 113   (req: > 3)
Antibodies: 349   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
5
13
10
3.2
99.3
mathematical ability
4
4
7
98.6
1
10
10
96.3
wellbeing measurement
3
5
8
96.3
neuroticism measurement
4
17
9
6.1
96
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
10
3.2
99.3
mathematical ability
7
98.6
10
96.3
wellbeing measurement
8
96.3
neuroticism measurement
9
6.1
96
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor 4
VGNC:13292
455432
Macaque
transcription factor 4
695814
Mouse
MGI:98506
21413
Rat
RGD:69271
84382
Dog
transcription factor 4
VGNC:47197
403949
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor 4
Macaque
transcription factor 4
Mouse
Rat
Dog
transcription factor 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15884-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (134)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the beta-catenin:TCF transactivating complex
Reactome
Myogenesis
Reactome
Signal Transduction
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the beta-catenin:TCF transactivating complex
Myogenesis
Signal Transduction
Signaling by WNT
Gene Ontology Terms (23)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (167)
1 – 10 of 167
HEXIM2
Tbio
Novelty: 0.14814693
p_int: 1
Score: 0.313
Data Source: BioPlex,STRINGDB
ID1
Tbio
Family: TF
Novelty: 0.00151069
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.924
Data Source: BioPlex,STRINGDB
RUNX1T1
Tbio
Novelty: 0.0039633
p_int: 0.999999976
p_ni: 8e-9
p_wrong: 1.6e-8
Score: 0.854
Data Source: BioPlex,STRINGDB
MYF6
Tbio
Family: TF
Novelty: 0.00509046
p_int: 0.999999942
p_ni: 5.8e-8
Score: 0.981
Data Source: BioPlex,STRINGDB
TWIST1
Tbio
Family: TF
Novelty: 0.0013639
p_int: 0.999999938
p_ni: 4e-9
p_wrong: 5.8e-8
Score: 0.734
Data Source: BioPlex,STRINGDB
FERD3L
Tbio
Family: TF
Novelty: 0.06797434
p_int: 0.999999927
p_ni: 7.3e-8
Score: 0.86
Data Source: BioPlex,STRINGDB
NEUROG3
Tbio
Family: TF
Novelty: 0.00341077
p_int: 0.999999926
p_ni: 7.4e-8
Score: 0.666
Data Source: BioPlex,STRINGDB
ID2
Tbio
Family: TF
Novelty: 0.00256364
p_int: 0.999999882
p_ni: 1.18e-7
Score: 0.89
Data Source: BioPlex,STRINGDB
NEUROD1
Tbio
Family: TF
Novelty: 0.00188624
p_int: 0.999999881
p_ni: 1.18e-7
p_wrong: 1e-9
Score: 0.937
Data Source: BioPlex,STRINGDB
HAND2
Tbio
Family: TF
Novelty: 0.00478924
p_int: 0.99999969
p_ni: 3.11e-7
Score: 0.514
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  410.90

PubMed score by year
PubTator Score  580.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: