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Tbio
CFAP410
Cilia- and flagella-associated protein 410

Protein Summary
Description
Plays a role in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Involved in DNA damage repair (PubMed:26290490). Four alternatively spliced transcript variants encoding four different isoforms have been found for this nuclear gene. All isoforms contain leucine-rich repeats. Three of these isoforms are mitochondrial proteins and one of them lacks the target peptide, so is not located in mitochondrion. This gene is down-regulated in Down syndrome (DS) brain, which may represent mitochondrial dysfunction in DS patients. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325223
  • ENSP00000317302
  • ENSG00000160226
  • ENST00000339818
  • ENSP00000344566
  • ENST00000397956
  • ENSP00000381047

Symbol
  • C21orf2
  • LRRC76
  • RDMS
  • SMDAX
  • LRRC76
  • YF5/A2
  • C21orf2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.25   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.25   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.6
86.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
86.5
Gene Ontology Terms (13)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (35)
1 – 10 of 35
TTC25
Tdark
Novelty: 0.23064129
p_int: 0.999995472
p_ni: 0.000004528
Score: 0.205
Data Source: BioPlex,STRINGDB
GIP
Tchem
Novelty: 0.0007219
p_int: 0.999930024
p_ni: 0.000060098
p_wrong: 0.000009878
Data Source: BioPlex
TEKT4
Tbio
Novelty: 0.05559086
p_int: 0.999924815
p_ni: 0.000075134
p_wrong: 5.2e-8
Score: 0.239
Data Source: BioPlex,STRINGDB
VTN
Tbio
Family: TF
Novelty: 0.00046861
p_int: 0.999859626
p_ni: 0.000140354
p_wrong: 1.9e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
SKAP1
Tbio
Family: Enzyme
Novelty: 0.03753848
p_int: 0.999630854
p_ni: 0.000369144
p_wrong: 2e-9
Data Source: BioPlex
ALS2
Tbio
Novelty: 0.0072324
p_int: 0.999524722
p_ni: 0.000474961
p_wrong: 3.17e-7
Score: 0.275
Data Source: BioPlex,STRINGDB
VPS26B
Tdark
Novelty: 0.25702869
p_int: 0.998471426
p_ni: 0.000396955
p_wrong: 0.001131619
Score: 0.2
Data Source: BioPlex,STRINGDB
KIF2B
Tbio
Novelty: 0.09958244
p_int: 0.995463403
p_ni: 0.002625879
p_wrong: 0.001910718
Score: 0.167
Data Source: BioPlex,STRINGDB
KCTD17
Tbio
Novelty: 0.12105733
p_int: 0.990772778
p_ni: 0.00662972
p_wrong: 0.002597502
Data Source: BioPlex
CAV3
Tbio
Novelty: 0.00190092
p_int: 0.986177874
p_ni: 0.012786508
p_wrong: 0.001035618
Data Source: BioPlex
Publication Statistics
PubMed Score  52.25

PubMed score by year
PubTator Score  10.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer