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Tbio
CHMP1A
Charged multivesicular body protein 1a

Protein Summary
Description
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397901
  • ENSP00000380998
  • ENSG00000131165

Symbol
  • CHMP1
  • KIAA0047
  • PCOLN3
  • PRSM1
  • PCH8
  • CHMP1
  • PRSM1
  • PCOLN3
  • VPS46A
  • VPS46-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
biological process
0.84
virus perturbation
0.79
cellular component
0.76
interacting protein
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.65   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.65   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
87.2
hair color
1
1
0
11.4
83.6
Calcium channel blocker use measurement
1
1
1
43.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
87.2
hair color
0
11.4
83.6
Calcium channel blocker use measurement
1
43.2
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (31)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (100)
1 – 10 of 100
STAMBP
Tbio
Novelty: 0.01543821
p_int: 0.999208936
p_ni: 0.000790885
p_wrong: 1.78e-7
Score: 0.809
Data Source: BioPlex,STRINGDB
IST1
Tbio
Novelty: 0.01780503
p_int: 0.998374576
p_ni: 0.001625314
p_wrong: 1.11e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
CHMP5
Tbio
Novelty: 0.03378716
p_int: 0.99791663
p_ni: 0.002083271
p_wrong: 1e-7
Score: 0.956
Data Source: BioPlex,STRINGDB
SIX2
Tbio
Family: TF
Novelty: 0.01046481
p_int: 0.993602606
p_ni: 0.006396824
p_wrong: 5.7e-7
Data Source: BioPlex
MEOX1
Tbio
Family: TF
Novelty: 0.02978667
p_int: 0.992855936
p_ni: 0.007143985
p_wrong: 7.8e-8
Score: 0.219
Data Source: BioPlex,STRINGDB
BROX
Tbio
Novelty: 0.16859864
p_int: 0.989867953
p_ni: 0.006385235
p_wrong: 0.003746812
Score: 0.44
Data Source: BioPlex,STRINGDB
VSX2
Tbio
Family: TF
Novelty: 0.0046733
p_int: 0.989025521
p_ni: 0.010974211
p_wrong: 2.68e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
HMGN2
Tbio
Novelty: 0.0080343
p_int: 0.986940777
p_ni: 0.013057815
p_wrong: 0.000001409
Score: 0.189
Data Source: BioPlex,STRINGDB
ZNF524
Tdark
Family: TF
Novelty: 2.44930764
p_int: 0.986270274
p_ni: 0.009883344
p_wrong: 0.003846382
Score: 0.227
Data Source: BioPlex,STRINGDB
LHX4
Tbio
Family: TF
Novelty: 0.02047732
p_int: 0.983208204
p_ni: 0.001817604
p_wrong: 0.014974192
Data Source: BioPlex
Publication Statistics
PubMed Score  23.65

PubMed score by year
PubTator Score  17.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer