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Tdark
CEP83
Centrosomal protein of 83 kDa

Protein Summary
Description
Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly. The protein encoded by this gene is a centriolar protein involved in primary cilium assembly. Defects in this gene have been associated with infantile nephronophthisis and intellectual disability. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339839
  • ENSP00000344655
  • ENSG00000173588
  • ENST00000397809
  • ENSP00000380911

Symbol
  • CCDC41
  • CCDC41
  • NPHP18
  • NY-REN-58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
tissue sample
0.62
transcription factor binding site profile
0.62
transcription factor
0.61
cell line
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.29   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.29   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (151)
1 – 10 of 151
POTEB2
Tdark
Novelty: 2.20408163
p_int: 0.999999988
p_ni: 1.2e-8
Data Source: BioPlex
POTEC
Tdark
Novelty: 6
p_int: 0.999999841
p_ni: 1.59e-7
Score: 0.672
Data Source: BioPlex,STRINGDB
PSMC5
Tbio
Family: Enzyme
Novelty: 0.01964643
p_int: 0.999997868
p_ni: 0.000002132
Data Source: BioPlex
HMG20A
Tbio
Family: TF
Novelty: 0.18049861
p_int: 0.999976737
p_ni: 2.6e-7
p_wrong: 0.000023003
Score: 0.175
Data Source: BioPlex,STRINGDB
USP7
Tchem
Family: Enzyme
Novelty: 0.00483735
p_int: 0.96687494
p_ni: 0.03312506
Score: 0.51
Data Source: BioPlex,STRINGDB
CKAP5
Tbio
Novelty: 0.00227797
p_int: 0.935275161
p_ni: 0.064724839
Score: 0.917
Data Source: BioPlex,STRINGDB
SCLT1
Tdark
Novelty: 0.23413981
Score: 0.993
Data Source: STRINGDB
CEP89
Tbio
Novelty: 0.37662532
Score: 0.991
Data Source: STRINGDB
FBF1
Tbio
Novelty: 0.00468904
Score: 0.981
Data Source: STRINGDB
CEP164
Tbio
Novelty: 0.07209475
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.29

PubMed score by year
PubTator Score  2.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer