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Tdark
PQLC1
PQ-loop repeat-containing protein 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357575
  • ENSP00000350188
  • ENSG00000122490
  • ENST00000397778
  • ENSP00000380880
  • ENST00000590381
  • ENSP00000465546

Symbol
  • SLC66A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
PubMedID
0.69
transcription factor binding site profile
0.61
transcription factor
0.6
cell line
0.57


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.65   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.65   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
79.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
79.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PQ loop repeat containing 1
VGNC:5196
738022
Macaque
PQ loop repeat containing 1
698716
Mouse
MGI:1914193
66943
Rat
RGD:1305223
361352
Dog
PQ loop repeat containing 1
VGNC:44935
476157
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PQ loop repeat containing 1
Macaque
PQ loop repeat containing 1
Mouse
Rat
Dog
PQ loop repeat containing 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N2U9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
GOC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (21)
1 – 10 of 21
TMEM44
Tdark
Novelty: 0.91167136
Score: 0.747
Data Source: STRINGDB
ATP9B
Tdark
Family: Transporter
Novelty: 0.18986483
Score: 0.66
Data Source: STRINGDB
CTNS
Tbio
Novelty: 0.00448623
Score: 0.636
Data Source: STRINGDB
ADI1
Tbio
Family: Enzyme
Novelty: 0.00908955
Score: 0.576
Data Source: STRINGDB
PQLC2
Tbio
Novelty: 0.19332453
Score: 0.574
Data Source: STRINGDB
HDHD3
Tdark
Family: Enzyme
Novelty: 0.51499634
Score: 0.568
Data Source: STRINGDB
MGLL
Tchem
Family: Enzyme
Novelty: 0.00196912
Score: 0.566
Data Source: STRINGDB
BRD9
Tchem
Family: Epigenetic
Novelty: 0.03450227
Score: 0.545
Data Source: STRINGDB
DROSHA
Tbio
Family: Enzyme
Novelty: 0.00107123
Score: 0.543
Data Source: STRINGDB
CLPTM1L
Tbio
Novelty: 0.01351819
Score: 0.523
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.65

PubMed score by year
PubTator Score  0.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer