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Tchem
LSS
Lanosterol synthase

Protein Summary
Description
Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356396
  • ENSP00000348762
  • ENSG00000160285
  • ENST00000397728
  • ENSP00000380837
  • ENST00000457828
  • ENSP00000409191
  • ENST00000522411
  • ENSP00000429133

Symbol
  • OSC
  • OSC
  • HYPT14
  • CTRCT44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
small molecule perturbation
0.8
transcription factor perturbation
0.8
histone modification site profile
0.76
gene perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.88   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.88   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 91
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (91)
1 – 10 of 91
CHEMBL304858,CHEMBL324162
chemical structure image
CHEMBL112210,CHEMBL67133
chemical structure image
CHEMBL481608,CHEMBL65230
chemical structure image
CHEMBL416694,CHEMBL114259
chemical structure image
CHEMBL66638,CHEMBL115085
chemical structure image
CHEMBL65024,CHEMBL543877
chemical structure image
CHEMBL445353
chemical structure image
CHEMBL479464
chemical structure image
CHEMBL277446
chemical structure image
CHEMBL65553
chemical structure image
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (26)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (118)
1 – 10 of 118
PNKD
Tbio
Family: Enzyme
Novelty: 0.02456078
p_int: 0.999993192
p_ni: 0.000006805
p_wrong: 3e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00062988
p_int: 0.999918519
p_ni: 0.000081474
p_wrong: 7e-9
Data Source: BioPlex
TNFRSF10A
Tchem
Novelty: 0.0003383
p_int: 0.999892211
p_ni: 0.000107735
p_wrong: 5.4e-8
Score: 0.153
Data Source: BioPlex,STRINGDB
LYPD4
Tbio
Novelty: 0.00381728
p_int: 0.986234719
p_ni: 0.009819359
p_wrong: 0.003945922
Data Source: BioPlex
GATD1
Tdark
Family: Enzyme
Novelty: 0.40291197
p_int: 0.984286651
p_ni: 0.004821261
p_wrong: 0.010892088
Data Source: BioPlex
GML
Tdark
Novelty: 0.04982168
p_int: 0.980959831
p_ni: 0.009792443
p_wrong: 0.009247726
Score: 0.173
Data Source: BioPlex,STRINGDB
CYP51A1
Tchem
Family: Enzyme
Novelty: 0.00127373
Score: 0.999
Data Source: STRINGDB
SQLE
Tchem
Family: Enzyme
Novelty: 0.0059338
Score: 0.998
Data Source: STRINGDB
MSMO1
Tbio
Family: Enzyme
Novelty: 0.01263528
Score: 0.992
Data Source: STRINGDB
FDFT1
Tchem
Family: Enzyme
Novelty: 0.00225882
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  124.88

PubMed score by year
PubTator Score  58.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer