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Tbio
IRF7
Interferon regulatory factor 7

Protein Summary
Description
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localiz ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330243
  • ENSP00000329411
  • ENSG00000185507
  • ENST00000348655
  • ENSP00000331803
  • ENST00000397566
  • ENSP00000380697
  • ENST00000397574
  • ENSP00000380704
  • ENST00000469048
  • ENSP00000434607
  • ENST00000525445
  • ENSP00000434009
  • ENST00000533182
  • ENSP00000433903
  • ENST00000612534
  • ENSP00000479615
  • ENSG00000276561
  • ENST00000621391
  • ENSP00000480358
  • ENST00000632827
  • ENSP00000488039
  • ENST00000633274
  • ENSP00000488591
  • ENST00000633943
  • ENSP00000488666
  • ENST00000634105
  • ENSP00000488581

Symbol
  • IMD39
  • IRF-7
  • IRF7A
  • IRF7B
  • IRF7C
  • IRF7H
  • IRF-7H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
biological process
0.98
gene perturbation
0.91
protein domain
0.85
hub protein
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.27   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 558   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.27   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 558   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
85.7
2
2
0
1.2
85.7
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
85.7
0
1.2
85.7
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (47)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (R-HSA-936964)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Reactome
Cytokine Signaling in Immune system
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Name
Explore in Pharos
Explore in Source
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Cytokine Signaling in Immune system
Cytosolic sensors of pathogen-associated DNA
DDX58/IFIH1-mediated induction of interferon-alpha/beta
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Gene Ontology Terms (37)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (389)
1 – 10 of 389
OASL
Tbio
Family: Enzyme
Novelty: 0.01502223
Score: 0.996
Data Source: STRINGDB
RSAD2
Tbio
Novelty: 0.0056473
Score: 0.995
Data Source: STRINGDB
ISG15
Tbio
Novelty: 0.00203781
Score: 0.995
Data Source: STRINGDB
DDX58
Tbio
Family: Enzyme
Novelty: 0.00080099
Score: 0.995
Data Source: Reactome,STRINGDB
MX1
Tbio
Novelty: 0.00072554
Score: 0.995
Data Source: STRINGDB
MYD88
Tbio
Novelty: 0.00037931
Score: 0.995
Data Source: Reactome,STRINGDB
IFIT3
Tbio
Novelty: 0.00568113
Score: 0.994
Data Source: STRINGDB
TBK1
Tchem
Family: Kinase
Novelty: 0.00194753
Score: 0.993
Data Source: Reactome,STRINGDB
IFIH1
Tbio
Family: Enzyme
Novelty: 0.00111499
Score: 0.993
Data Source: Reactome,STRINGDB
IRAK1
Tchem
Family: Kinase
Novelty: 0.00170873
Score: 0.992
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  435.27

PubMed score by year
PubTator Score  288.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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