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Tbio
AKAP8L
A-kinase anchor protein 8-like

Protein Summary
Description
Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be invol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397410
  • ENSP00000380557
  • ENSG00000011243
  • ENST00000595465
  • ENSP00000470952

Symbol
  • NAKAP
  • NAKAP95
  • HA95
  • HAP95
  • NAKAP
  • NAKAP95
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
interacting protein
0.89
transcription factor binding site profile
0.87
virus perturbation
0.79
small molecule perturbation
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.75   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.75   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (23)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (33)
1 – 10 of 33
DHX9
Tbio
Family: Enzyme
Novelty: 0.00130907
Score: 0.859
Data Source: STRINGDB
RNF43
Tbio
Family: Enzyme
Novelty: 0.01258908
Score: 0.857
Data Source: STRINGDB
PRPF40A
Tbio
Novelty: 0.00898047
Score: 0.842
Data Source: STRINGDB
HTT
Tchem
Novelty: 0.00034051
Score: 0.693
Data Source: STRINGDB
TP53BP1
Tbio
Family: Epigenetic
Novelty: 0.00131256
Score: 0.673
Data Source: STRINGDB
LBR
Tbio
Family: Epigenetic
Novelty: 0.00205961
Score: 0.641
Data Source: STRINGDB
EMD
Tbio
Novelty: 0.00135202
Score: 0.619
Data Source: STRINGDB
SFPQ
Tbio
Novelty: 0.01207637
Score: 0.583
Data Source: STRINGDB
GLB1
Tchem
Family: Enzyme
Novelty: 0.00241713
Score: 0.583
Data Source: STRINGDB
MCMBP
Tbio
Novelty: 0.13330215
Score: 0.577
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.75

PubMed score by year
PubTator Score  10.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer