Tbio INS Insulin

Protein Classes

DTO Classes

Insulin-degrading Enzyme / Insulin-like Growth Factor 2 Mrna-binding Protein 1 / Insulin-like Growth Factor 2 Mrna-binding Protein 2 / Insulin-like Growth Factor 2 Mrna-binding Protein 3 / Early Placenta Insulin-like Peptide / Insulin-like Peptide Insl6 / Insulin-like Growth Factor-binding Protein 2 / Insulin-like Growth Factor-binding Protein 6 / Insulin-like Growth Factor-binding Protein 1 / Insulin-like Growth Factor-binding Protein 5 / Insulin-like Growth Factor-binding Protein 3 / Insulin-like Growth Factor-binding Protein 4 / Insulin-like Growth Factor-binding Protein Complex Acid Labile Subunit / Insulin Gene Enhancer Protein Isl-1 / Insulin Gene Enhancer Protein Isl-2 / Insulin Receptor / Insulin Receptor-related Protein / Insulin-like Growth Factor 1 Receptor / Glucose-dependent Insulinotropic Receptor / Insulinoma Cell / Insulinoma / Hyperinsulinemic Hypoglycemia / Hyperinsulinism / Insulin-like 3

Protein Summary

Description

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2019]

Uniprot Accession IDs

• P01308
• Q5EEX2

Gene Name

• INS

Ensembl ID

• ENST00000250971
• ENSP00000250971
• ENSG00000254647
• ENST00000381330
• ENSP00000370731
• ENST00000397262
• ENSP00000380432

Symbol

• IDDM
• ILPR
• IRDN
• IDDM1
• IDDM2
• MODY10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
chemical	1
phenotype	0.76
disease perturbation	0.74

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155642.44   (req: < 5)

Gene RIFs: 666   (req: <= 3)

Antibodies: 3206   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155642.44   (req: >= 5)

Gene RIFs: 666   (req: > 3)

Antibodies: 3206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 68

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (266)

1 – 5 of 266

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (99)

Reactome (34)

KEGG (28)

PathwayCommons (18)

WikiPathways (19)

Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 5 of 34

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amyloid fiber formation	79 targets	R-HSA-977225
Reactome	Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Reactome	COPI-mediated anterograde transport	83 targets	R-HSA-6807878
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	ER to Golgi Anterograde Transport	136 targets	R-HSA-199977

Name	Explore in Pharos	Explore in Source
Amyloid fiber formation	79 targets	R-HSA-977225
Asparagine N-linked glycosylation	286 targets	R-HSA-446203
COPI-mediated anterograde transport	83 targets	R-HSA-6807878
Developmental Biology	1055 targets	R-HSA-1266738
ER to Golgi Anterograde Transport	136 targets	R-HSA-199977

Gene Ontology Terms (77)

Functions (5)

Components (9)

Processes (63)

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
insulin receptor binding	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
insulin-like growth factor receptor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
protease binding	Inferred from Physical Interaction (IPI)	UniProtKB
hormone activity	Inferred from Mutant Phenotype (IMP)	BHF-UCL

Protein-Protein Interactions (1651)

Explore Interacting Targets

1 – 10 of 1651

• See Interactions on String-DB

UBR2

Tbio

Family: Enzyme

Novelty: 0.03319944

p_int: 0.997933351

p_ni: 0.002066649

Data Source: BioPlex

SEMA3C

Tbio

Novelty: 0.00902769

p_int: 0.991541059

p_ni: 0.008273882

p_wrong: 0.000185059

Score: 0.212

Data Source: BioPlex,STRINGDB

COL14A1

Tbio

Novelty: 0.00758642

p_int: 0.990133439

p_ni: 0.00986656

p_wrong: 2e-9

Score: 0.166

Data Source: BioPlex,STRINGDB

PXYLP1

Tbio

Family: Enzyme

Novelty: 0.00920316

p_int: 0.976147025

p_ni: 0.023591093

p_wrong: 0.000261882

Data Source: BioPlex

SULF2

Tbio

Family: Enzyme

Novelty: 0.01443436

p_int: 0.97231979

p_ni: 0.027680091

p_wrong: 1.19e-7

Score: 0.524

Data Source: BioPlex,STRINGDB

HSPA5

Tchem

Novelty: 0.00051387

p_int: 0.96774504

p_ni: 0.03225496

Score: 0.587

Data Source: BioPlex,STRINGDB

UBR1

Tbio

Family: Enzyme

Novelty: 0.00742688

p_int: 0.946314856

p_ni: 0.053685144

Data Source: BioPlex

CHST10

Tbio

Family: Enzyme

Novelty: 0.06875665

p_int: 0.941505825

p_ni: 0.058492797

p_wrong: 0.000001378

Data Source: BioPlex

PRSS12

Tbio

Novelty: 0.03177005

p_int: 0.921444542

p_ni: 0.000040009

p_wrong: 0.078515449

Data Source: BioPlex

ERAP1

Tchem

Family: Enzyme

Novelty: 0.00447092

p_int: 0.906928059

p_ni: 0.093071941

Score: 0.315

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  155642.44

PubMed score by year

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PubTator Score  62986.53

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGG

1-70

GPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

70-110

MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN

Find similar targets by:

Uniprot Keyword

3D-structure
Alternative splicing
Carbohydrate metabolism
Cleavage on pair of basic residues
Complete proteome
Diabetes mellitus
Direct protein sequencing
Disease mutation
Disulfide bond
Glucose metabolism