Protein Classes
Protein Summary
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2019]
- ENST00000250971
- ENSP00000250971
- ENSG00000254647
- ENST00000381330
- ENSP00000370731
- ENST00000397262
- ENSP00000380432
- IDDM
- ILPR
- IRDN
- IDDM1
- IDDM2
- MODY10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
phenotype | 0.76 | ||
disease perturbation | 0.74 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 155642.44 (req: < 5)
Gene RIFs: 666 (req: <= 3)
Antibodies: 3206 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 155642.44 (req: >= 5)
Gene RIFs: 666 (req: > 3)
Antibodies: 3206 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 68
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (266)
1 – 5 of 266
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (99)
Reactome (34)
KEGG (28)
PathwayCommons (18)
WikiPathways (19)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 34
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Amyloid fiber formation | ||||
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPI-mediated anterograde transport | ||||
Reactome | Developmental Biology | ||||
Reactome | ER to Golgi Anterograde Transport | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Amyloid fiber formation | ||||
Asparagine N-linked glycosylation | ||||
COPI-mediated anterograde transport | ||||
Developmental Biology | ||||
ER to Golgi Anterograde Transport | ||||
Gene Ontology Terms (77)
Functions (5)
Components (9)
Processes (63)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Protein-Protein Interactions (1651)
1 – 10 of 1651
UBR2
Family: Enzyme
Novelty: 0.03319944
p_int: 0.997933351
p_ni: 0.002066649
Data Source: BioPlex
SEMA3C
Novelty: 0.00902769
p_int: 0.991541059
p_ni: 0.008273882
p_wrong: 0.000185059
Score: 0.212
Data Source: BioPlex,STRINGDB
COL14A1
Novelty: 0.00758642
p_int: 0.990133439
p_ni: 0.00986656
p_wrong: 2e-9
Score: 0.166
Data Source: BioPlex,STRINGDB
PXYLP1
Family: Enzyme
Novelty: 0.00920316
p_int: 0.976147025
p_ni: 0.023591093
p_wrong: 0.000261882
Data Source: BioPlex
SULF2
Family: Enzyme
Novelty: 0.01443436
p_int: 0.97231979
p_ni: 0.027680091
p_wrong: 1.19e-7
Score: 0.524
Data Source: BioPlex,STRINGDB
HSPA5
Novelty: 0.00051387
p_int: 0.96774504
p_ni: 0.03225496
Score: 0.587
Data Source: BioPlex,STRINGDB
UBR1
Family: Enzyme
Novelty: 0.00742688
p_int: 0.946314856
p_ni: 0.053685144
Data Source: BioPlex
CHST10
Family: Enzyme
Novelty: 0.06875665
p_int: 0.941505825
p_ni: 0.058492797
p_wrong: 0.000001378
Data Source: BioPlex
PRSS12
Novelty: 0.03177005
p_int: 0.921444542
p_ni: 0.000040009
p_wrong: 0.078515449
Data Source: BioPlex
ERAP1
Family: Enzyme
Novelty: 0.00447092
p_int: 0.906928059
p_ni: 0.093071941
Score: 0.315
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 155642.44
PubMed score by year
PubTator Score 62986.53
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGG
1-70
GPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN
70-110
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN
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