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Tbio
PAFAH1B1
Platelet-activating factor acetylhydrolase IB subunit alpha

Protein Summary
Description
Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397195
  • ENSP00000380378
  • ENSG00000007168

Symbol
  • LIS1
  • MDCR
  • MDS
  • PAFAHA
  • MDS
  • LIS1
  • LIS2
  • MDCR
  • NudF
  • PAFAH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
transcription factor perturbation
1
disease perturbation
0.99
virus perturbation
0.94
protein domain
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.33   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.33   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 60
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (39)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Anchoring of the basal body to the plasma membrane
COPI-independent Golgi-to-ER retrograde traffic
Gene Ontology Terms (79)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (407)
1 – 10 of 407
NDEL1
Tbio
Novelty: 0.01425912
p_int: 0.999984197
p_ni: 0.000015803
Score: 0.999
Data Source: BioPlex,STRINGDB
PAFAH1B3
Tbio
Family: Enzyme
Novelty: 0.10410642
p_int: 0.967764622
p_ni: 0.032235378
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
NDE1
Tbio
Novelty: 0.01199577
Score: 0.998
Data Source: STRINGDB
DYNC1H1
Tbio
Novelty: 0.01357869
Score: 0.997
Data Source: Reactome,STRINGDB
DCTN1
Tbio
Novelty: 0.00789738
Score: 0.997
Data Source: Reactome,STRINGDB
PAFAH1B2
Tchem
Family: Enzyme
Novelty: 0.11764706
Score: 0.996
Data Source: Reactome,STRINGDB
NUDC
Tbio
Novelty: 0.020707
Score: 0.995
Data Source: STRINGDB
CLIP1
Tbio
Novelty: 0.00253519
Score: 0.991
Data Source: STRINGDB
DCTN2
Tbio
Novelty: 0.01298814
Score: 0.99
Data Source: Reactome,STRINGDB
BICD2
Tbio
Novelty: 0.02508993
Score: 0.985
Data Source: STRINGDB
Publication Statistics
PubMed Score  342.33

PubMed score by year
PubTator Score  279.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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