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Tbio
TULP3
Tubby-related protein 3

Protein Summary
Description
Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis. This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397132
  • ENSP00000380321
  • ENSG00000078246
  • ENST00000448120
  • ENSP00000410051
  • ENST00000540184
  • ENSP00000444110

Symbol
  • TUBL3
  • TUBL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
histone modification site profile
0.83
kinase perturbation
0.81
transcription factor perturbation
0.8
transcription factor binding site profile
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.72   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.72   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
38.6
mean reticulocyte volume
1
1
1
23
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
38.6
mean reticulocyte volume
1
23
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubby like protein 3
VGNC:13488
451753
Macaque
tubby like protein 3
709100
Mouse
MGI:1329045
22158
Rat
RGD:1585259
688749
Dog
tubby like protein 3
VGNC:47998
611832
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubby like protein 3
Macaque
tubby like protein 3
Mouse
Rat
Dog
tubby like protein 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75386-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Hedgehog 'off' state (R-HSA-5610787)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hedgehog 'off' state
Reactome
Signal Transduction
Reactome
Signaling by Hedgehog
Name
Explore in Pharos
Explore in Source
Hedgehog 'off' state
Signal Transduction
Signaling by Hedgehog
Gene Ontology Terms (33)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (112)
1 – 10 of 112
TTC21B
Tbio
Novelty: 0.02480259
p_int: 0.999999975
p_ni: 2.2e-8
p_wrong: 4e-9
Score: 0.976
Data Source: BioPlex,Reactome,STRINGDB
WDR35
Tbio
Novelty: 0.02958717
p_int: 0.999999805
p_ni: 1.29e-7
p_wrong: 6.6e-8
Score: 0.982
Data Source: BioPlex,Reactome,STRINGDB
ANKRD54
Tbio
Novelty: 0.03101679
p_int: 0.999999622
p_ni: 1.08e-7
p_wrong: 2.7e-7
Score: 0.544
Data Source: BioPlex,STRINGDB
LYSMD1
Tdark
Novelty: 1.59161703
p_int: 0.999998253
p_ni: 1.6e-8
p_wrong: 0.000001731
Score: 0.219
Data Source: BioPlex,STRINGDB
WDR19
Tbio
Novelty: 0.037197
p_int: 0.999996466
p_ni: 0.000003534
Score: 0.972
Data Source: BioPlex,Reactome,STRINGDB
IFT43
Tbio
Novelty: 0.00478274
p_int: 0.999995422
p_ni: 0.000004578
Score: 0.664
Data Source: BioPlex,STRINGDB
IFT140
Tbio
Novelty: 0.02872897
p_int: 0.999991783
p_ni: 0.000008216
p_wrong: 1e-9
Score: 0.978
Data Source: BioPlex,Reactome,STRINGDB
ARIH1
Tbio
Family: Enzyme
Novelty: 0.0258739
p_int: 0.999991184
p_ni: 0.000008816
Data Source: BioPlex
FOXK2
Tbio
Family: TF
Novelty: 0.01420141
p_int: 0.999973559
p_ni: 0.000026441
Score: 0.181
Data Source: BioPlex,STRINGDB
IFT122
Tbio
Novelty: 0.02235986
p_int: 0.999942805
p_ni: 0.000057195
Score: 0.982
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  16.72

PubMed score by year
PubTator Score  6.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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