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Tbio
BICRA
BRD4-interacting chromatin-remodeling complex-associated protein

Protein Summary
Description
Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396720
  • ENSP00000379946
  • ENSG00000063169

Symbol
  • GLTSCR1
  • GLTSCR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.39   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.39   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
85.1
balding measurement
1
1
1
77.8
Age-related nuclear cataract
1
1
0
5.7
39.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
85.1
balding measurement
1
77.8
Age-related nuclear cataract
0
5.7
39.3
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (46)
1 – 10 of 46
BCL7C
Tdark
Novelty: 0.31203802
p_int: 0.999999914
p_ni: 8.6e-8
Score: 0.947
Data Source: BioPlex,STRINGDB
SMARCD1
Tbio
Novelty: 0.03176642
p_int: 0.999999785
p_ni: 2.14e-7
p_wrong: 2e-9
Score: 0.722
Data Source: BioPlex,STRINGDB
SS18
Tbio
Novelty: 0.00915548
p_int: 0.999999669
p_ni: 3.28e-7
p_wrong: 3e-9
Score: 0.954
Data Source: BioPlex,STRINGDB
BCL7A
Tbio
Novelty: 0.07026394
p_int: 0.999999079
p_ni: 9.2e-7
Score: 0.927
Data Source: BioPlex,STRINGDB
SPATA1
Tdark
p_int: 0.905782255
p_ni: 0.094215928
p_wrong: 0.000001817
Data Source: BioPlex
BCL7B
Tbio
Novelty: 0.11909054
Score: 0.77
Data Source: STRINGDB
SS18L1
Tbio
Novelty: 0.10255799
Score: 0.757
Data Source: STRINGDB
NOP53
Tbio
Novelty: 0.00353077
Score: 0.715
Data Source: STRINGDB
SYMPK
Tbio
Novelty: 0.01773552
Score: 0.595
Data Source: STRINGDB
NSD3
Tbio
Family: Epigenetic
Novelty: 0.02371017
Score: 0.592
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.39

PubMed score by year
PubTator Score  4.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer