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Tbio
HLA-A
HLA class I histocompatibility antigen, A-69 alpha chain

Protein Summary
Description
Involved in the presentation of foreign antigens to the immune system. HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles hav ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000457879
  • ENSP00000403575
  • ENSG00000235657

Symbol
  • HLAA
  • HLAA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4250.03   (req: < 5)
Gene RIFs: 476   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4250.03   (req: >= 5)
Gene RIFs: 476   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (48)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (334)
1 – 10 of 334
SLC3A2
Tbio
Family: Transporter
Novelty: 0.00258645
p_int: 0.920922309
p_ni: 0.079077691
Data Source: BioPlex
CLEC4A
Tbio
Novelty: 0.02222451
p_int: 0.919883907
p_ni: 0.080116093
Data Source: BioPlex
HFE
Tbio
Novelty: 0.00040976
p_int: 0.892979558
p_ni: 0.107020442
Data Source: BioPlex
SCGB2A1
Tbio
Novelty: 0.00455624
p_int: 0.859333539
p_ni: 0.140666461
Data Source: BioPlex
CD1A
Tbio
Novelty: 0.00133941
p_int: 0.830311951
p_ni: 0.169688049
Score: 0.17
Data Source: BioPlex,STRINGDB
B3GALT5
Tbio
Family: Enzyme
Novelty: 0.05431281
p_int: 0.752411539
p_ni: 0.247588461
Data Source: BioPlex
B2M
Tbio
Novelty: 0.00012184
Score: 0.999
Data Source: STRINGDB
LILRB1
Tbio
Novelty: 0.0062396
Score: 0.996
Data Source: STRINGDB
PDIA3
Tbio
Family: Enzyme
Novelty: 0.00326508
Score: 0.992
Data Source: STRINGDB
CD8A
Tbio
Novelty: 0.00003113
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  4250.03

PubMed score by year
PubTator Score  4624.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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