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Tbio
GNE
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Protein Classes
Protein Summary
Description
Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alte ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377902
  • ENSP00000367134
  • ENSG00000159921
  • ENST00000396594
  • ENSP00000379839
  • ENST00000447283
  • ENSP00000414760
  • ENST00000539208
  • ENSP00000445117
  • ENST00000539815
  • ENSP00000439155
  • ENST00000543356
  • ENSP00000437765
  • ENST00000642385
  • ENSP00000494141

Symbol
  • GLCNE
  • NM
  • DMRV
  • IBM2
  • Uae1
  • GLCNE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
molecular function
0.99
kinase perturbation
0.91
gene perturbation
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.57   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.57   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
VGNC:8890
465094
Macaque
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
693525
Mouse
MGI:1354951
50798
Rat
RGD:69239
114711
Dog
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
VGNC:51721
481607
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Macaque
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Mouse
Rat
Dog
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y223-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2
Reactome
Disease
Reactome
Diseases associated with glycosylation precursor biosynthesis
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2
Disease
Diseases associated with glycosylation precursor biosynthesis
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (114)
1 – 10 of 114
C2orf68
Tdark
Novelty: 0.7947239
p_int: 0.999999886
p_ni: 1.12e-7
p_wrong: 3e-9
Score: 0.507
Data Source: BioPlex,STRINGDB
LGALS3BP
Tbio
Novelty: 0.0025302
p_int: 0.999951299
p_ni: 5.65e-7
p_wrong: 0.000048136
Score: 0.181
Data Source: BioPlex,STRINGDB
ZNF764
Tdark
Family: TF
Novelty: 0.76308829
p_int: 0.999767485
p_ni: 0.0002325
p_wrong: 1.6e-8
Score: 0.161
Data Source: BioPlex,STRINGDB
TIMM50
Tbio
Family: Enzyme
Novelty: 0.0238053
p_int: 0.999600422
p_ni: 0.000394337
p_wrong: 0.000005241
Score: 0.189
Data Source: BioPlex,STRINGDB
ZNF213
Tdark
Family: TF
Novelty: 0.24190639
p_int: 0.999514229
p_ni: 0.000484464
p_wrong: 0.000001307
Data Source: BioPlex
NANS
Tbio
Family: Enzyme
Novelty: 0.00718044
Score: 0.989
Data Source: STRINGDB
RENBP
Tbio
Family: Enzyme
Novelty: 0.02220005
Score: 0.987
Data Source: STRINGDB
UAP1
Tbio
Family: Enzyme
Novelty: 0.02034314
Score: 0.97
Data Source: STRINGDB
NPL
Tbio
Family: Enzyme
Novelty: 0.00944797
Score: 0.957
Data Source: STRINGDB
UAP1L1
Tdark
Family: Enzyme
Novelty: 0.36065169
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  344.57

PubMed score by year
PubTator Score  217.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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