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Tdark
ATF7IP2
Activating transcription factor 7-interacting protein 2

Protein Summary
Description
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324570
  • ENSP00000322811
  • ENSG00000166669
  • ENST00000356427
  • ENSP00000348799
  • ENST00000396559
  • ENSP00000379807
  • ENST00000396560
  • ENSP00000379808

Symbol
  • MCAF2
  • MCAF2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.72
transcription factor
0.7
gene perturbation
0.56
microRNA
0.51
tissue sample
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.47   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.47   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.7
3.7
disease progression measurement
1
1
0
1.7
3.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
3.7
disease progression measurement
0
1.7
3.7
Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (13)
1 – 10 of 13
SETDB1
Tbio
Family: TF; Epigenetic
Novelty: 0.00609294
Score: 0.856
Data Source: STRINGDB
GTF2E2
Tbio
Novelty: 0.18033153
Score: 0.641
Data Source: STRINGDB
GTF2E1
Tbio
Novelty: 0.39883299
Score: 0.546
Data Source: STRINGDB
TCEAL1
Tbio
Novelty: 0.02210924
Score: 0.542
Data Source: STRINGDB
MBD1
Tbio
Family: TF
Novelty: 0.02644475
Score: 0.537
Data Source: STRINGDB
MASTL
Tbio
Family: Kinase
Novelty: 0.01266037
Score: 0.52
Data Source: STRINGDB
ERCC3
Tbio
Family: Enzyme
Novelty: 0.00978601
Score: 0.506
Data Source: STRINGDB
ERCC2
Tbio
Family: Enzyme
Novelty: 0.00240155
Score: 0.489
Data Source: STRINGDB
DEPDC1
Tbio
Novelty: 0.04255829
Score: 0.484
Data Source: STRINGDB
ATF7
Tbio
Family: TF
Novelty: 0.01470313
Score: 0.468
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.47

PubMed score by year
PubTator Score  0.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer