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Tbio
IQSEC2
IQ motif and SEC7 domain-containing protein 2

Protein Summary
Description
Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins. This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375365
  • ENSP00000364514
  • ENSG00000124313
  • ENST00000396435
  • ENSP00000379712
  • ENST00000639161
  • ENSP00000491796
  • ENST00000642864
  • ENSP00000495726

Symbol
  • KIAA0522
  • MRX1
  • BRAG1
  • MRX18
  • MRX78
  • IQ-ArfGEF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
cell type or tissue
0.76
protein domain
0.73
small molecule perturbation
0.62
cell line
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.23   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.23   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
42.7
neutrophil count
1
1
1
17.5
monocyte percentage of leukocytes
1
1
1
8.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
42.7
neutrophil count
1
17.5
monocyte percentage of leukocytes
1
8.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
IQ motif and Sec7 domain 2
702562
Mouse
MGI:3528396
245666
Dog
IQ motif and Sec7 domain 2
VGNC:42084
491895
Horse
IQ motif and Sec7 domain 2 [Source:HGNC Symbol;Acc:HGNC:29059]
Cow
IQ motif and Sec7 domain 2
VGNC:30262
517311
Species
Name
OMA
EggNOG
Inparanoid
Macaque
IQ motif and Sec7 domain 2
Mouse
Dog
IQ motif and Sec7 domain 2
Horse
IQ motif and Sec7 domain 2 [Source:HGNC Symbol;Acc:HGNC:29059]
Cow
IQ motif and Sec7 domain 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (49)
1 – 10 of 49
APBA2
Tbio
Novelty: 0.01654185
p_int: 0.999992598
p_ni: 0.000007354
p_wrong: 4.8e-8
Score: 0.228
Data Source: BioPlex,STRINGDB
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
p_int: 0.999898948
p_ni: 0.000085721
p_wrong: 0.000015331
Data Source: BioPlex
THBS3
Tbio
Novelty: 0.01915634
p_int: 0.999354666
p_ni: 0.000192214
p_wrong: 0.00045312
Score: 0.208
Data Source: BioPlex,STRINGDB
ARF1
Tchem
Family: Enzyme
Novelty: 0.00208554
Score: 0.973
Data Source: STRINGDB
ARF3
Tbio
Family: Enzyme
Novelty: 0.00336831
Score: 0.764
Data Source: STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.764
Data Source: STRINGDB
ARL17A
Tdark
Family: Enzyme
Novelty: 0.37276049
Score: 0.739
Data Source: STRINGDB
ARF6
Tbio
Family: Enzyme
Novelty: 0.00278138
Score: 0.722
Data Source: STRINGDB
KCNJ4
Tchem
Family: IC
Novelty: 0.0093539
Score: 0.718
Data Source: STRINGDB
ARHGEF9
Tbio
Novelty: 0.01577146
Score: 0.688
Data Source: STRINGDB
Publication Statistics
PubMed Score  62.23

PubMed score by year
PubTator Score  27.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer