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Tbio
CCHCR1
Coiled-coil alpha-helical rod protein 1

Protein Summary
Description
May be a regulator of keratinocyte proliferation or differentiation. This gene encodes a protein with five coiled-coil alpha-helical rod domains that is thought to act as a regulator of mRNA metabolism through its interaction with mRNA-decapping protein 4. It localizes to P-bodies, the site of mRNA metabolism, with an N-terminus that is required for this subcellular localization, suggesting it is a P-body component. Naturally occurring mutations in this gene are associated with psoriasis. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376266
  • ENSP00000365442
  • ENSG00000204536
  • ENST00000383341
  • ENSP00000372832
  • ENSG00000206355
  • ENST00000383527
  • ENSP00000373019
  • ENSG00000206457
  • ENST00000396268
  • ENSP00000379566
  • ENST00000400352
  • ENSP00000383205
  • ENST00000400412
  • ENSP00000383263
  • ENST00000416163
  • ENSP00000408012
  • ENSG00000234114
  • ENST00000425620
  • ENSP00000393042
  • ENST00000451521
  • ENSP00000401039

Symbol
  • C6orf18
  • HCR
  • HCR
  • SBP
  • pg8
  • C6orf18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
disease perturbation
0.74
phenotype
0.73
virus
0.66
cellular component
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.27   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.27   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (64)
Items per page:
1 – 5 of 64
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2.7
92.6
1
1
0
2.7
92.6
1
1
0
2.7
92.6
1
1
0
2.7
92.6
1
1
0
1.1
83
Items per page:
1 – 5 of 64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.7
92.6
0
2.7
92.6
0
2.7
92.6
0
2.7
92.6
0
1.1
83
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (109)
1 – 10 of 109
NUP62
Tbio
Novelty: 0.01432724
p_int: 0.99999944
p_ni: 5.6e-7
Data Source: BioPlex
IQCC
Tdark
Novelty: 1.83536118
p_int: 0.999998923
p_ni: 0.000001077
Score: 0.403
Data Source: BioPlex,STRINGDB
WASHC3
Tdark
Novelty: 0.18307321
p_int: 0.999998049
p_ni: 0.000001951
Score: 0.199
Data Source: BioPlex,STRINGDB
FGFR1OP2
Tbio
Novelty: 0.1082136
p_int: 0.999982537
p_ni: 0.000017463
Data Source: BioPlex
LTBR
Tbio
Novelty: 0.003823
p_int: 0.999691929
p_ni: 0.00030791
p_wrong: 1.62e-7
Data Source: BioPlex
CCDC183
Tdark
Novelty: 1.55719016
p_int: 0.999516929
p_ni: 0.000483071
Score: 0.159
Data Source: BioPlex,STRINGDB
MAGEA10
Tbio
Novelty: 0.05364393
p_int: 0.999286557
p_ni: 0.000713435
p_wrong: 8e-9
Data Source: BioPlex
HSBP1
Tbio
Novelty: 0.09422832
p_int: 0.999093362
p_ni: 0.000906594
p_wrong: 4.3e-8
Data Source: BioPlex
SNAP29
Tbio
Novelty: 0.02009206
p_int: 0.998444235
p_ni: 0.0015546
p_wrong: 0.000001165
Data Source: BioPlex
DTNBP1
Tbio
Novelty: 0.00341619
p_int: 0.99800221
p_ni: 0.001997786
p_wrong: 4e-9
Score: 0.161
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  39.27

PubMed score by year
PubTator Score  90.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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