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Tbio
CTAGE5
Endoplasmic reticulum export factor CTAGE5

Protein Summary
Description
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites. This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Sep 2016]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.38   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.38   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (70)
1 – 10 of 70
CTAGE1
Tbio
Novelty: 0.14119958
p_int: 1
Score: 0.216
Data Source: BioPlex,STRINGDB
CTAGE8
Tdark
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.204
Data Source: BioPlex,STRINGDB
CTAGE6
Tdark
Novelty: 52
p_int: 0.999999858
p_ni: 1.42e-7
Score: 0.734
Data Source: BioPlex,STRINGDB
MIA3
Tbio
Novelty: 0.02784348
p_int: 0.999999716
p_ni: 2.84e-7
Score: 0.988
Data Source: BioPlex,STRINGDB
SLC39A5
Tbio
Family: Transporter
Novelty: 0.05205571
p_int: 0.999997892
p_ni: 0.000002108
Data Source: BioPlex
ATF1
Tchem
Family: TF
Novelty: 0.01450941
p_int: 0.999987921
p_ni: 0.000012069
p_wrong: 1e-8
Data Source: BioPlex
ANO6
Tbio
Family: IC
Novelty: 0.01288434
p_int: 0.999983553
p_ni: 0.000016447
Score: 0.211
Data Source: BioPlex,STRINGDB
SRPRB
Tbio
Novelty: 0.04735362
p_int: 0.999967282
p_ni: 0.000032717
p_wrong: 1e-9
Score: 0.533
Data Source: BioPlex,STRINGDB
RGPD8
Tdark
Novelty: 0.12397737
p_int: 0.999936162
p_ni: 0.000063838
Data Source: BioPlex
SERPINA12
Tbio
Novelty: 0.00549132
p_int: 0.999828982
p_ni: 0.000171007
p_wrong: 1.1e-8
Score: 0.167
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  25.38

PubMed score by year
PubTator Score  20.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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