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Tbio
EDA2R
Tumor necrosis factor receptor superfamily member 27

Protein Summary
Description
Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253392
  • ENSP00000253392
  • ENSG00000131080
  • ENST00000374719
  • ENSP00000363851
  • ENST00000396050
  • ENSP00000379365
  • ENST00000451436
  • ENSP00000415242

Symbol
  • TNFRSF27
  • XEDAR
  • XEDAR
  • EDAA2R
  • EDA-A2R
  • TNFRSF27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
tissue sample
0.63
biological process
0.6
microRNA
0.5
biological term
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.61   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.61   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
estradiol measurement
1
1
1
67.1
testosterone measurement
1
1
1
49
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
estradiol measurement
1
67.1
testosterone measurement
1
49
Pathways (7)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Protein-Protein Interactions (33)
1 – 10 of 33
TRAF3
Tbio
Novelty: 0.0022525
p_int: 0.999974501
p_ni: 0.000025498
p_wrong: 1e-9
Score: 0.619
Data Source: BioPlex,STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
p_int: 0.999773863
p_ni: 0.00021294
p_wrong: 0.000013197
Score: 0.904
Data Source: BioPlex,STRINGDB
ICAM1
Tchem
Novelty: 0.00009746
p_int: 0.996539541
p_ni: 0.003451234
p_wrong: 0.000009225
Score: 0.39
Data Source: BioPlex,STRINGDB
TRAF1
Tbio
Novelty: 0.00526776
p_int: 0.989307219
p_ni: 0.010692781
Score: 0.701
Data Source: BioPlex,STRINGDB
HSDL1
Tdark
Family: Enzyme
Novelty: 0.24066595
p_int: 0.944192526
p_ni: 0.055807473
Score: 0.173
Data Source: BioPlex,STRINGDB
TK1
Tchem
Family: Kinase
Novelty: 0.00139343
p_int: 0.930512336
p_ni: 0.069487664
Score: 0.261
Data Source: BioPlex,STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
p_int: 0.870133462
p_ni: 0.12986653
p_wrong: 8e-9
Score: 0.685
Data Source: BioPlex,STRINGDB
ATP2B4
Tbio
Family: Transporter
Novelty: 0.00560356
p_int: 0.831817646
p_ni: 0.168182164
p_wrong: 1.9e-7
Data Source: BioPlex
EDA
Tbio
Novelty: 0.00352464
Score: 0.963
Data Source: Reactome,STRINGDB
SLC24A5
Tbio
Family: Transporter
Novelty: 0.01224635
Score: 0.747
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.61

PubMed score by year
PubTator Score  18.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer