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Tbio
MOB1A
MOB kinase activator 1A

Protein Summary
Description
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is al ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396049
  • ENSP00000379364
  • ENSG00000114978

Symbol
  • C2orf6
  • MOB4B
  • MOBK1B
  • MOBKL1B
  • MOB1
  • MATS1
  • Mob4B
  • C2orf6
  • MOBK1B
  • MOBKL1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
transcription factor perturbation
0.91
protein complex
0.89
hub protein
0.82


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.32   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.32   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MOB kinase activator 1A
VGNC:322
459544
Macaque
MOB kinase activator 1A
707984
Mouse
MGI:2442631
232157
Rat
RGD:1307014
297387
Dog
MOB kinase activator 1A
VGNC:43299
612924
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MOB kinase activator 1A
Macaque
MOB kinase activator 1A
Mouse
Rat
Dog
MOB kinase activator 1A
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H8S9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (45)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Hippo
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Hippo
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (63)
1 – 10 of 63
MOB1B
Tbio
Family: Enzyme
Novelty: 0.0718959
p_int: 1
Score: 0.985
Data Source: BioPlex,STRINGDB
STK38L
Tchem
Family: Kinase
Novelty: 0.05193219
p_int: 0.999999894
p_ni: 1.06e-7
Score: 0.972
Data Source: BioPlex,STRINGDB
ANXA7
Tbio
Novelty: 0.00365221
p_int: 0.991560433
p_ni: 0.008438426
p_wrong: 0.000001141
Score: 0.687
Data Source: BioPlex,STRINGDB
STK4
Tchem
Family: Kinase
Novelty: 0.02104423
Score: 0.999
Data Source: Reactome,STRINGDB
LATS1
Tbio
Family: Kinase
Novelty: 0.00369058
Score: 0.999
Data Source: Reactome,STRINGDB
STK3
Tchem
Family: Kinase
Novelty: 0.0529257
Score: 0.998
Data Source: Reactome,STRINGDB
LATS2
Tchem
Family: Kinase
Novelty: 0.00521035
Score: 0.996
Data Source: Reactome,STRINGDB
YAP1
Tbio
Novelty: 0.00124225
Score: 0.982
Data Source: STRINGDB
SAV1
Tbio
Novelty: 0.00962335
Score: 0.982
Data Source: STRINGDB
WWTR1
Tbio
Novelty: 0.00431186
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  47.32

PubMed score by year
PubTator Score  33.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer