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Tbio
ADNP
Activity-dependent neuroprotector homeobox protein

Protein Summary
Description
Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349014
  • ENSP00000342905
  • ENSG00000101126
  • ENST00000371602
  • ENSP00000360662
  • ENST00000396029
  • ENSP00000379346
  • ENST00000396032
  • ENSP00000379349
  • ENST00000621696
  • ENSP00000483881

Symbol
  • ADNP1
  • KIAA0784
  • ADNP1
  • HVDAS
  • MRD28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor binding site profile
0.94
histone modification site profile
0.72
PubMedID
0.72
transcription factor
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.09   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 319   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.09   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 319   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
84.6
prostate carcinoma
1
1
0
1.1
61.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
84.6
prostate carcinoma
0
1.1
61.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activity dependent neuroprotector homeobox
VGNC:13829
458336
Macaque
activity dependent neuroprotector homeobox
701422
Mouse
MGI:1338758
11538
Rat
RGD:71030
64622
Dog
activity dependent neuroprotector homeobox
VGNC:37662
485927
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activity dependent neuroprotector homeobox
Macaque
activity dependent neuroprotector homeobox
Mouse
Rat
Dog
activity dependent neuroprotector homeobox
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H2P0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (28)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (77)
1 – 10 of 77
ZNF581
Tdark
Family: TF
Novelty: 18
p_int: 0.999999935
p_ni: 4.8e-8
p_wrong: 1.7e-8
Score: 0.23
Data Source: BioPlex,STRINGDB
ZNF524
Tdark
Family: TF
Novelty: 2.44930764
p_int: 0.999999666
p_ni: 3.33e-7
p_wrong: 1e-9
Score: 0.23
Data Source: BioPlex,STRINGDB
DAXX
Tbio
Novelty: 0.00348585
p_int: 0.999993895
p_ni: 0.000006105
Data Source: BioPlex
ZKSCAN8
Tbio
Family: TF
Novelty: 0.17881042
p_int: 0.999531476
p_ni: 0.000468496
p_wrong: 2.8e-8
Data Source: BioPlex
THRSP
Tbio
Novelty: 0.00938864
p_int: 0.99926677
p_ni: 0.000733229
Data Source: BioPlex
ZSCAN20
Tdark
Family: TF
Novelty: 0.37441538
p_int: 0.99903714
p_ni: 0.000962849
p_wrong: 1.1e-8
Data Source: BioPlex
POLG2
Tbio
Family: Enzyme
Novelty: 0.0233323
p_int: 0.998361656
p_ni: 0.001638344
Score: 0.23
Data Source: BioPlex,STRINGDB
PIP
Tbio
Novelty: 0.00208509
p_int: 0.996957451
p_ni: 0.003042543
p_wrong: 6e-9
Data Source: BioPlex
EIF3D
Tbio
Novelty: 0.0360717
p_int: 0.981691189
p_ni: 0.018308745
p_wrong: 6.6e-8
Data Source: BioPlex
ABTB2
Tdark
Novelty: 0.45729157
p_int: 0.96142732
p_ni: 0.038569469
p_wrong: 0.000003211
Data Source: BioPlex
Publication Statistics
PubMed Score  155.09

PubMed score by year
PubTator Score  56.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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