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Tdark
MTHFD2L
Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2

Protein Classes
Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325278
  • ENSP00000321984
  • ENSG00000163738
  • ENST00000395759
  • ENSP00000379108
  • ENST00000429519
  • ENSP00000391327
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor perturbation
0.8
protein domain
0.73
tissue sample
0.67
transcription factor
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.76   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.76   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
79.2
total cholesterol measurement
1
1
1
63.6
low density lipoprotein cholesterol measurement
1
1
1
47.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
79.2
total cholesterol measurement
1
63.6
low density lipoprotein cholesterol measurement
1
47.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
461253
Macaque
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
702907
Mouse
MGI:1915871
665563
Rat
RGD:1310879
305248
Dog
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
VGNC:51777
482197
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
Macaque
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
Mouse
Rat
Dog
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H903-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (68)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of folate and pterines
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of folate and pterines
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Protein-Protein Interactions (74)
1 – 10 of 74
MTHFD2
Tchem
Family: Enzyme
Novelty: 0.01776594
p_int: 0.999999709
p_ni: 6.8e-8
p_wrong: 2.23e-7
Score: 0.98
Data Source: BioPlex,STRINGDB
HENMT1
Tdark
Family: Enzyme
Novelty: 0.17427834
p_int: 0.999963441
p_ni: 0.000036556
p_wrong: 3e-9
Score: 0.228
Data Source: BioPlex,STRINGDB
PROSER2
Tdark
Novelty: 0.56334611
p_int: 0.999716759
p_ni: 0.000283217
p_wrong: 2.4e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
SRP9
Tbio
Novelty: 0.02243103
p_int: 0.998680253
p_ni: 0.000028084
p_wrong: 0.001291663
Score: 0.719
Data Source: BioPlex,STRINGDB
LAMTOR5
Tbio
Novelty: 0.003692
p_int: 0.992707331
p_ni: 0.000382542
p_wrong: 0.006910127
Data Source: BioPlex
HDHD3
Tdark
Family: Enzyme
Novelty: 0.51499634
p_int: 0.933117282
p_ni: 0.00000275
p_wrong: 0.066879968
Score: 0.514
Data Source: BioPlex,STRINGDB
BTLA
Tbio
Novelty: 0.00770048
p_int: 0.895478608
p_ni: 0.005072549
p_wrong: 0.099448843
Data Source: BioPlex
CST4
Tbio
Novelty: 0.00773554
p_int: 0.831269983
p_ni: 0.039383672
p_wrong: 0.129346345
Score: 0.183
Data Source: BioPlex,STRINGDB
GART
Tclin
Novelty: 0.00524985
Score: 0.992
Data Source: STRINGDB
SHMT1
Tbio
Family: Enzyme
Novelty: 0.00200739
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.76

PubMed score by year
PubTator Score  3.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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