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Tclin
TYMP
Thymidine phosphorylase

Protein Summary
Description
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252029
  • ENSP00000252029
  • ENSG00000025708
  • ENST00000395678
  • ENSP00000379036
  • ENST00000395680
  • ENSP00000379037
  • ENST00000395681
  • ENSP00000379038

Symbol
  • ECGF1
  • TP
  • ECGF
  • ECGF1
  • MNGIE
  • MEDPS1
  • MTDPS1
  • PDECGF
  • hPD-ECGF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.85
protein domain
0.85
disease
0.71
tissue sample
0.65
biological process
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 609.26   (req: < 5)
Gene RIFs: 121   (req: <= 3)
Antibodies: 755   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 609.26   (req: >= 5)
Gene RIFs: 121   (req: > 3)
Antibodies: 755   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
tipiracil
chemical structure image
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
2
2
89.1
mean corpuscular hemoglobin concentration
1
1
1
82.4
mean corpuscular hemoglobin
2
2
2
82
red blood cell distribution width
1
1
1
47.7
hemoglobin measurement
1
1
1
14.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
89.1
mean corpuscular hemoglobin concentration
1
82.4
mean corpuscular hemoglobin
2
82
red blood cell distribution width
1
47.7
hemoglobin measurement
1
14.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thymidine phosphorylase
VGNC:5982
458941
Macaque
thymidine phosphorylase
716161
Mouse
MGI:1920212
72962
Rat
RGD:1305756
315219
Horse
thymidine phosphorylase
VGNC:24688
100146854
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thymidine phosphorylase
Macaque
thymidine phosphorylase
Mouse
Rat
Horse
thymidine phosphorylase
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P19971-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Nucleotide salvage
Reactome
Pyrimidine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Nucleotide salvage
Pyrimidine catabolism
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (102)
1 – 10 of 102
KLHL11
Tbio
Novelty: 0.1537041
p_int: 0.99993833
p_ni: 0.000061669
p_wrong: 1e-9
Data Source: BioPlex
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.999897598
p_ni: 0.000102402
Score: 0.205
Data Source: BioPlex,STRINGDB
TEFM
Tbio
Novelty: 0.10836617
p_int: 0.999870408
p_ni: 0.000129592
Data Source: BioPlex
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.999848319
p_ni: 0.000151681
Data Source: BioPlex
GPATCH2L
Tdark
Novelty: 1.68490464
p_int: 0.999818257
p_ni: 0.000181743
Score: 0.173
Data Source: BioPlex,STRINGDB
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.999707575
p_ni: 0.000292425
Data Source: BioPlex
PDE4DIP
Tbio
Novelty: 0.03414104
p_int: 0.999193331
p_ni: 0.000806669
Data Source: BioPlex
YJU2
Tdark
Novelty: 0.75647391
p_int: 0.997996622
p_ni: 0.002003378
Data Source: BioPlex
SUSD3
Tdark
Novelty: 0.43699506
p_int: 0.994229778
p_ni: 0.005761562
p_wrong: 0.00000866
Score: 0.18
Data Source: BioPlex,STRINGDB
SINHCAF
Tdark
Novelty: 0.18692832
p_int: 0.993710714
p_ni: 0.006288702
p_wrong: 5.84e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  609.26

PubMed score by year
PubTator Score  538.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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