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Tbio
TIMM9
Mitochondrial import inner membrane translocase subunit Tim9

Protein Summary
Description
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395159
  • ENSP00000378588
  • ENSG00000100575
  • ENST00000555061
  • ENSP00000450638
  • ENST00000555404
  • ENSP00000451198
  • ENST00000555593
  • ENSP00000451006

Symbol
  • TIM9
  • TIM9A
  • TIMM9A
  • TIM9
  • TIM9A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
disease perturbation
0.9
transcription factor binding site profile
0.88
gene perturbation
0.78
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.2   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.2   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Protein-Protein Interactions (124)
1 – 10 of 124
TIMM10
Tbio
Family: Enzyme
Novelty: 0.02727463
p_int: 0.999965209
p_ni: 0.000034791
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TIMM13
Tdark
Family: Enzyme
Novelty: 0.04802297
Score: 0.999
Data Source: STRINGDB
TIMM8A
Tbio
Family: Enzyme
Novelty: 0.00954602
Score: 0.996
Data Source: STRINGDB
TIMM22
Tbio
Family: Enzyme
Novelty: 0.12627933
Score: 0.993
Data Source: Reactome,STRINGDB
TIMM8B
Tbio
Family: Enzyme
Novelty: 0.02843625
Score: 0.989
Data Source: STRINGDB
TIMM23
Tbio
Family: Enzyme
Novelty: 0.06463808
Score: 0.987
Data Source: STRINGDB
TIMM17A
Tbio
Family: Enzyme
Novelty: 0.02095904
Score: 0.984
Data Source: STRINGDB
TOMM40
Tbio
Novelty: 0.0041507
Score: 0.983
Data Source: STRINGDB
TIMM17B
Tdark
Family: Enzyme
Novelty: 0.03556998
Score: 0.969
Data Source: STRINGDB
TIMM10B
Tdark
Family: Enzyme
Novelty: 0.36798313
Score: 0.965
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  31.20

PubMed score by year
PubTator Score  12.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer