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Tbio
SPP1
Osteopontin

Protein Summary
Description
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237623
  • ENSP00000237623
  • ENSG00000118785
  • ENST00000360804
  • ENSP00000354042
  • ENST00000395080
  • ENSP00000378517
  • ENST00000614857
  • ENSP00000477824

Symbol
  • BNSP
  • OPN
  • OPN
  • BNSP
  • BSPI
  • ETA-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
1
chemical
0.96
transcription factor perturbation
0.96
biological process
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7585.46   (req: < 5)
Gene RIFs: 854   (req: <= 3)
Antibodies: 1318   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7585.46   (req: >= 5)
Gene RIFs: 854   (req: > 3)
Antibodies: 1318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (45)
Degradation of the extracellular matrix (R-HSA-1474228)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Integrin cell surface interactions
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Extracellular matrix organization
Gene expression (Transcription)
Generic Transcription Pathway
Integrin cell surface interactions
Gene Ontology Terms (26)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (433)
1 – 10 of 433
CD44
Tbio
Novelty: 0.00011321
Score: 0.992
Data Source: Reactome,STRINGDB
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.98
Data Source: Reactome,STRINGDB
MMP7
Tchem
Family: Enzyme
Novelty: 0.00080093
Score: 0.979
Data Source: Reactome,STRINGDB
TIMP1
Tbio
Family: Enzyme
Novelty: 0.00020986
Score: 0.978
Data Source: STRINGDB
ALB
Tchem
Novelty: 0.00000616
Score: 0.978
Data Source: STRINGDB
IL6
Tclin
Novelty: 0.00001819
Score: 0.978
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.977
Data Source: STRINGDB
FAM20C
Tbio
Family: Enzyme
Novelty: 0.00318966
Score: 0.975
Data Source: STRINGDB
MMP3
Tchem
Novelty: 0.00041675
Score: 0.972
Data Source: Reactome,STRINGDB
ITGAV
Tchem
Novelty: 0.00148589
Score: 0.971
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  7585.46

PubMed score by year
PubTator Score  3108.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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