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Tbio
GPT
Alanine aminotransferase 1

Protein Summary
Description
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394955
  • ENSP00000378408
  • ENSG00000167701
  • ENST00000528431
  • ENSP00000433586

Symbol
  • AAT1
  • GPT1
  • AAT1
  • ALT1
  • GPT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.99
disease
0.95
biological term
0.79
gene perturbation
0.7
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16527.92   (req: < 5)
Gene RIFs: 108   (req: <= 3)
Antibodies: 365   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16527.92   (req: >= 5)
Gene RIFs: 108   (req: > 3)
Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (19)
Alanine metabolism (R-HSA-8964540)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Alanine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Alanine metabolism
Metabolism
Metabolism of amino acids and derivatives
Protein-Protein Interactions (277)
1 – 10 of 277
GPT2
Tbio
Family: Enzyme
Novelty: 0.00544179
p_int: 0.999996993
p_wrong: 0.000003007
Score: 0.81
Data Source: BioPlex,STRINGDB
GOT1
Tbio
Family: Enzyme
Novelty: 0.00607491
Score: 0.97
Data Source: STRINGDB
GOT2
Tbio
Family: Enzyme
Novelty: 0.00062666
Score: 0.962
Data Source: STRINGDB
GLUD1
Tbio
Family: Enzyme
Novelty: 0.00439505
Score: 0.952
Data Source: STRINGDB
GLUD2
Tbio
Family: Enzyme
Novelty: 0.01939618
Score: 0.948
Data Source: STRINGDB
AGXT
Tbio
Family: Enzyme
Novelty: 0.00130886
Score: 0.927
Data Source: STRINGDB
ALB
Tchem
Novelty: 0.0000092
Score: 0.924
Data Source: STRINGDB
OGDH
Tbio
Family: Enzyme
Novelty: 0.01059143
Score: 0.921
Data Source: STRINGDB
NAGS
Tbio
Family: Enzyme
Novelty: 0.00459624
Score: 0.919
Data Source: STRINGDB
F2
Tclin
Family: Enzyme
Novelty: 0.00006072
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  16527.92

PubMed score by year
PubTator Score  7779.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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