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Tbio
SIN3A
Paired amphipathic helix protein Sin3a

Protein Summary
Description
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360439
  • ENSP00000353622
  • ENSG00000169375
  • ENST00000394947
  • ENSP00000378402
  • ENST00000394949
  • ENSP00000378403

Symbol
  • WITKOS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
0.99
drug perturbation
0.96
interacting protein
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.27   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.27   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
2
2
69.2
1
1
0
1.1
42.4
mean platelet volume
1
1
1
35.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
69.2
0
1.1
42.4
mean platelet volume
1
35.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SIN3 transcription regulator family member A
VGNC:1878
453759
Macaque
SIN3 transcription regulator family member A
705719
Mouse
MGI:107157
20466
Rat
RGD:1311598
363067
Dog
SIN3 transcription regulator family member A
VGNC:46177
478372
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SIN3 transcription regulator family member A
Macaque
SIN3 transcription regulator family member A
Mouse
Rat
Dog
SIN3 transcription regulator family member A
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96ST3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (48)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Epigenetic regulation of gene expression
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Reactome
Factors involved in megakaryocyte development and platelet production
Name
Explore in Pharos
Explore in Source
Disease
Epigenetic regulation of gene expression
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Factors involved in megakaryocyte development and platelet production
Gene Ontology Terms (44)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (380)
1 – 10 of 380
SINHCAF
Tdark
Novelty: 0.18692832
p_int: 0.99999991
p_ni: 8.7e-8
p_wrong: 3e-9
Score: 0.965
Data Source: BioPlex,STRINGDB
RBBP7
Tbio
Novelty: 0.01795364
p_int: 0.99999512
p_ni: 0.00000488
Score: 0.981
Data Source: BioPlex,STRINGDB
ING2
Tbio
Family: Epigenetic
Novelty: 0.02424031
p_int: 0.999989874
p_ni: 0.000010126
Score: 0.994
Data Source: BioPlex,STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.999984978
p_ni: 0.000015022
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
ZNF704
Tdark
Novelty: 0.34442716
p_int: 0.999866907
p_ni: 0.000133093
Score: 0.655
Data Source: BioPlex,STRINGDB
SUDS3
Tbio
Family: Enzyme
Novelty: 0.03837881
p_int: 0.999787348
p_ni: 0.000212649
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
MXD3
Tbio
Family: TF
Novelty: 0.07436584
p_int: 0.99969809
p_ni: 0.00030191
Score: 0.742
Data Source: BioPlex,STRINGDB
MIER2
Tbio
Novelty: 0.85226416
p_int: 0.999324351
p_ni: 0.000675623
p_wrong: 2.6e-8
Score: 0.225
Data Source: BioPlex,STRINGDB
PHF23
Tbio
Family: Epigenetic
Novelty: 0.17699844
p_int: 0.999286649
p_ni: 0.000713351
Score: 0.715
Data Source: BioPlex,STRINGDB
MAX
Tbio
Family: TF
Novelty: 0.00799068
p_int: 0.995700337
p_ni: 0.004299662
p_wrong: 1e-9
Score: 0.965
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  105.27

PubMed score by year
PubTator Score  137.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer