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Tbio
INCENP
Inner centromere protein

Protein Summary
Description
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the ki ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278849
  • ENSP00000278849
  • ENSG00000149503
  • ENST00000394818
  • ENSP00000378295
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
transcription factor binding site profile
0.9
cellular component
0.89
ligand (protein) perturbation
0.83
small molecule perturbation
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.78   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.78   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
2
2
1
1.1
65.5
sex hormone-binding globulin measurement
2
1
2
63.2
1
1
1
46.8
1
1
1
46.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
1
1.1
65.5
sex hormone-binding globulin measurement
2
63.2
1
46.8
1
46.8
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (25)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (19)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (255)
1 – 10 of 255
EIF2B5
Tbio
Novelty: 0.0102209
p_int: 0.999999878
p_ni: 1.22e-7
Data Source: BioPlex
BIRC5
Tchem
Novelty: 0.00332112
p_int: 0.999995311
p_ni: 5.33e-7
p_wrong: 0.000004156
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
AURKC
Tchem
Family: Kinase
Novelty: 0.00950433
p_int: 0.999989338
p_ni: 0.000008903
p_wrong: 0.000001759
Score: 0.998
Data Source: BioPlex,STRINGDB
AURKB
Tchem
Family: Kinase
Novelty: 0.00100972
Score: 0.999
Data Source: Reactome,STRINGDB
CDCA8
Tbio
Novelty: 0.01448513
Score: 0.999
Data Source: Reactome,STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.998
Data Source: STRINGDB
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
Score: 0.997
Data Source: STRINGDB
KIF23
Tbio
Novelty: 0.00719651
Score: 0.996
Data Source: STRINGDB
CENPE
Tchem
Novelty: 0.00458125
Score: 0.996
Data Source: STRINGDB
BUB1
Tchem
Family: Kinase
Novelty: 0.00327514
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score  127.78

PubMed score by year
PubTator Score  72.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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