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Tbio
SFMBT1
Scm-like with four MBT domains protein 1

Protein Summary
Description
Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis. This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394752
  • ENSP00000378235
  • ENSG00000163935

Symbol
  • RU1
  • RU1
  • SFMBT
  • hSFMBT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.76
protein domain
0.73
microRNA
0.71
histone modification site profile
0.7
biological process
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.59   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.59   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
2
3
95.8
intelligence
3
3
1
6.9
93
cognitive function measurement
1
1
1
72.4
self reported educational attainment
1
1
1
67.8
worry measurement
1
1
0
7.5
44.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
95.8
intelligence
1
6.9
93
cognitive function measurement
1
72.4
self reported educational attainment
1
67.8
worry measurement
0
7.5
44.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Scm like with four mbt domains 1
694961
Mouse
MGI:1859609
54650
Rat
RGD:61999
58967
Dog
Scm like with four mbt domains 1
VGNC:46076
484728
Horse
Scm like with four mbt domains 1
VGNC:22895
100051403
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Scm like with four mbt domains 1
Mouse
Rat
Dog
Scm like with four mbt domains 1
Horse
Scm like with four mbt domains 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UHJ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
Name
Explore in Pharos
Explore in Source
Endoderm Differentiation
Endoderm Differentiation
Endoderm Differentiation
Endoderm Differentiation
Endoderm Differentiation
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (59)
1 – 10 of 59
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.999999262
p_ni: 2.14e-7
p_wrong: 5.24e-7
Score: 0.592
Data Source: BioPlex,STRINGDB
HMG20A
Tbio
Family: TF
Novelty: 0.11994252
p_int: 0.999998499
p_ni: 2.3e-8
p_wrong: 0.000001478
Score: 0.825
Data Source: BioPlex,STRINGDB
PSMB8
Tclin
Family: Enzyme
Novelty: 0.00189046
Score: 0.747
Data Source: STRINGDB
PSMB9
Tchem
Family: Enzyme
Novelty: 0.0016249
Score: 0.716
Data Source: STRINGDB
BHLHA9
Tbio
Family: TF
Novelty: 0.05522751
Score: 0.678
Data Source: STRINGDB
LRRC56
Tdark
Novelty: 1.32360532
Score: 0.663
Data Source: STRINGDB
TMEM171
Tdark
Novelty: 2.00247773
Score: 0.649
Data Source: STRINGDB
B3GNT4
Tbio
Family: Enzyme
Novelty: 0.47935258
Score: 0.649
Data Source: STRINGDB
UBE2Q2
Tbio
Novelty: 0.12491522
Score: 0.645
Data Source: STRINGDB
KDM1A
Tchem
Family: Epigenetic
Novelty: 0.00142673
Score: 0.634
Data Source: STRINGDB
Publication Statistics
PubMed Score  320.59

PubMed score by year
PubTator Score  69.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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