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Tbio
EFEMP1
EGF-containing fibulin-like extracellular matrix protein 1

Protein Classes
Protein Summary
Description
Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355426
  • ENSP00000347596
  • ENSG00000115380
  • ENST00000394555
  • ENSP00000378058

Symbol
  • FBLN3
  • FBNL
  • DHRD
  • DRAD
  • FBNL
  • MLVT
  • MTLV
  • S1-5
  • FBLN3
  • FIBL-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
viral protein
0.93
protein domain
0.92
PubMedID
0.89
virus
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.38   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 358   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.38   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
9
2
9
5.8
98.7
vital capacity
2
2
1
21.1
95.8
white matter hyperintensity measurement
4
2
3
9.1
93.6
BMI-adjusted waist circumference
6
2
19
86.8
refractive error measurement
1
1
1
83.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
9
5.8
98.7
vital capacity
1
21.1
95.8
white matter hyperintensity measurement
3
9.1
93.6
BMI-adjusted waist circumference
19
86.8
refractive error measurement
1
83.4
Pathways (3)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Molecules associated with elastic fibres
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (85)
1 – 10 of 85
ZNF747
Tdark
Novelty: 9
p_int: 0.999998436
p_ni: 0.000001539
p_wrong: 2.5e-8
Data Source: BioPlex
FBLN2
Tbio
Novelty: 0.01340024
p_int: 0.999996844
p_ni: 0.000003142
p_wrong: 1.3e-8
Score: 0.922
Data Source: BioPlex,STRINGDB
ZNF628
Tdark
Family: TF
Novelty: 0.50407457
p_int: 0.999989912
p_ni: 4e-7
p_wrong: 0.000009688
Score: 0.352
Data Source: BioPlex,STRINGDB
ZNF398
Tbio
Family: TF
Novelty: 0.01578856
p_int: 0.999988712
p_ni: 0.000011278
p_wrong: 1e-8
Data Source: BioPlex
ZNF627
Tdark
Family: TF
Novelty: 0.34605017
p_int: 0.999982907
p_ni: 0.000017088
p_wrong: 5e-9
Data Source: BioPlex
ZNF408
Tbio
Family: TF
Novelty: 0.10649477
p_int: 0.999981995
p_ni: 4.91e-7
p_wrong: 0.000017514
Data Source: BioPlex
ZBTB9
Tdark
Novelty: 0.95590016
p_int: 0.999949121
p_ni: 0.000050821
p_wrong: 5.8e-8
Score: 0.167
Data Source: BioPlex,STRINGDB
ZNF358
Tdark
Family: TF
Novelty: 0.77495044
p_int: 0.999948968
p_ni: 0.000019616
p_wrong: 0.000031416
Score: 0.195
Data Source: BioPlex,STRINGDB
ZNF444
Tdark
Family: TF
Novelty: 0.21564163
p_int: 0.999883278
p_ni: 0.000116722
Data Source: BioPlex
ZNF316
Tdark
Novelty: 1.0869977
p_int: 0.999777866
p_ni: 0.000222134
Data Source: BioPlex
Publication Statistics
PubMed Score  205.38

PubMed score by year
PubTator Score  130.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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