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Tbio
CACNB1
Voltage-dependent L-type calcium channel subunit beta-1

Protein Summary
Description
Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:8107964, PubMed:15615847). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344140
  • ENSP00000345461
  • ENSG00000067191
  • ENST00000394303
  • ENSP00000377840
  • ENST00000394310
  • ENSP00000377847

Symbol
  • CACNLB1
  • CAB1
  • CCHLB1
  • CACNLB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
molecular function
0.79
co-expressed gene
0.76
virus perturbation
0.76
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.6   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 370   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.6   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 370   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (26)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Muscle contraction
Reactome
NCAM signaling for neurite out-growth
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Muscle contraction
NCAM signaling for neurite out-growth
Protein-Protein Interactions (124)
1 – 10 of 124
CACNB2
Tbio
Family: IC
Novelty: 0.02869423
p_int: 0.999999981
p_ni: 1e-9
p_wrong: 1.8e-8
Score: 0.959
Data Source: BioPlex,STRINGDB
CACNB3
Tbio
Family: IC
Novelty: 0.06538322
p_int: 0.999999897
p_ni: 1.03e-7
Score: 0.93
Data Source: BioPlex,STRINGDB
CBARP
Tbio
Novelty: 0.00284707
p_int: 0.999961336
p_ni: 0.000038664
Score: 0.823
Data Source: BioPlex,STRINGDB
KLHL15
Tbio
Novelty: 0.68181818
p_int: 0.998815913
p_ni: 0.001184083
p_wrong: 5e-9
Score: 0.175
Data Source: BioPlex,STRINGDB
WDR75
Tbio
Novelty: 0.35651969
p_int: 0.758537765
p_ni: 0.241210508
p_wrong: 0.000251727
Score: 0.241
Data Source: BioPlex,STRINGDB
CACNA2D1
Tclin
Family: IC
Novelty: 0.0266267
Score: 0.998
Data Source: Reactome,STRINGDB
CACNG1
Tbio
Family: IC
Novelty: 0.174255
Score: 0.997
Data Source: STRINGDB
CACNA1D
Tclin
Family: IC
Novelty: 0.00242625
Score: 0.995
Data Source: Reactome,STRINGDB
CACNA1C
Tclin
Family: IC
Novelty: 0.00152799
Score: 0.992
Data Source: Reactome,STRINGDB
CACNA1S
Tclin
Family: IC
Novelty: 0.00562075
Score: 0.99
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  7.60

PubMed score by year
PubTator Score  6.18

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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