Tbio GPC3 Glypican-3

Protein Summary

Description

Cell surface proteoglycan that bears heparan sulfate (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity). Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• P51654
• C9JLE3
• G3V1R0
• Q2L880
• Q2L882

Gene Name

• GPC3

Ensembl ID

• ENST00000370818
• ENSP00000359854
• ENSG00000147257
• ENST00000394299
• ENSP00000377836
• ENST00000631057
• ENSP00000486325

Symbol

• OCI5
• SGB
• DGSX
• MXR7
• SDYS
• SGBS
• OCI-5
• SGBS1
• GTR2-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
disease perturbation	0.98
PubMedID	0.89
biological term	0.85
small molecule perturbation	0.83

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 972.18   (req: < 5)

Gene RIFs: 160   (req: <= 3)

Antibodies: 1325   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 972.18   (req: >= 5)

Gene RIFs: 160   (req: > 3)

Antibodies: 1325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (32)

Reactome (28)

KEGG (1)

PathwayCommons (3)

A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 5 of 28

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
Reactome	Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185
Reactome	Defective B3GALT6 causes EDSP2 and SEMDJL1	20 targets	R-HSA-4420332
Reactome	Defective B3GAT3 causes JDSSDHD	20 targets	R-HSA-3560801
Reactome	Defective B4GALT7 causes EDS, progeroid type	20 targets	R-HSA-3560783

Name	Explore in Pharos	Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185
Defective B3GALT6 causes EDSP2 and SEMDJL1	20 targets	R-HSA-4420332
Defective B3GAT3 causes JDSSDHD	20 targets	R-HSA-3560801
Defective B4GALT7 causes EDS, progeroid type	20 targets	R-HSA-3560783

Gene Ontology Terms (41)

Functions (1)

Components (7)

Processes (33)

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
peptidyl-dipeptidase inhibitor activity	Inferred from Direct Assay (IDA)	UniProtKB

Protein-Protein Interactions (292)

Explore Interacting Targets

1 – 10 of 292

• See Interactions on String-DB

TRIM68

Tbio

Family: Enzyme

Novelty: 0.27820711

p_int: 0.999990096

p_ni: 0.000009904

Data Source: BioPlex

HADHA

Tbio

Novelty: 0.00234785

p_int: 0.999988857

p_ni: 0.000011143

Data Source: BioPlex

CAMKV

Tbio

Family: Kinase

Novelty: 0.02297481

p_int: 0.999978855

p_ni: 0.000021145

Score: 0.15

Data Source: BioPlex,STRINGDB

RAB34

Tbio

Family: Enzyme

Novelty: 0.01573742

p_int: 0.999972365

p_ni: 0.000025588

p_wrong: 0.000002047

Data Source: BioPlex

PARP16

Tbio

Family: Enzyme

Novelty: 0.02664352

p_int: 0.999921321

p_ni: 0.000067727

p_wrong: 0.000010952

Data Source: BioPlex

ULBP1

Tbio

Novelty: 0.02190147

p_int: 0.999739799

p_ni: 0.000260201

Score: 0.189

Data Source: BioPlex,STRINGDB

GPR183

Tchem

Family: GPCR

Novelty: 0.021257

p_int: 0.999735258

p_ni: 0.000264724

p_wrong: 1.8e-8

Data Source: BioPlex

LRRTM4

Tbio

Novelty: 0.17645205

p_int: 0.999528347

p_ni: 0.000471652

p_wrong: 1e-9

Score: 0.333

Data Source: BioPlex,STRINGDB

RAP1A

Tchem

Family: Enzyme

Novelty: 0.00466391

p_int: 0.999397747

p_ni: 0.000596169

p_wrong: 0.000006084

Data Source: BioPlex

ODAPH

Tbio

Novelty: 0.49135043

p_int: 0.998774298

p_ni: 0.00118123

p_wrong: 0.000044472

Data Source: BioPlex

Publication Statistics

PubMed Score  972.18

PubMed score by year

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PubTator Score  535.32

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGP

1-70

TCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQ

70-140

AFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQLMNPGLPDSALDINECLRGARRDLKVFGN

140-210

FPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNV

210-280

VMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTIGKLCA

280-350

HSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDT

350-420

LCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSMPKGRVLDKNLDE

420-490

EGFESGDCGDDEDECIGGSGDGMIKVKNQLRFLAELAYDLDVDDAPGNSQQATPKDNEISTFHNLGNVHS

490-560

PLKLLTSMAISVVCFFFLVH

560-580

MAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQLMNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSMPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLRFLAELAYDLDVDDAPGNSQQATPKDNEISTFHNLGNVHSPLKLLTSMAISVVCFFFLVH

Find similar targets by:

Uniprot Keyword

Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
GPI-anchor
Heparan sulfate
Lipoprotein