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Tbio
ANXA4
Annexin A4

Protein Summary
Description
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394295
  • ENSP00000377833
  • ENSG00000196975
  • ENST00000536030
  • ENSP00000441931

Symbol
  • ANX4
  • ANX4
  • P32.5
  • PIG28
  • PP4-X
  • ZAP36
  • PAP-II
  • HEL-S-274
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.99
transcription factor perturbation
0.98
interacting protein
0.96
small molecule perturbation
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 431.37   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 458   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 431.37   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 458   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
64.3
C-reactive protein measurement
1
1
1
45.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
64.3
C-reactive protein measurement
1
45.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
annexin A4
VGNC:17
459542
Macaque
annexin A4
701433
Mouse
MGI:88030
11746
Rat
RGD:621171
79124
Dog
annexin A4
VGNC:37941
606756
Species
Name
OMA
EggNOG
Inparanoid
Chimp
annexin A4
Macaque
annexin A4
Mouse
Rat
Dog
annexin A4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P09525-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (25)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (59)
1 – 10 of 59
SF3A3
Tbio
Novelty: 0.03815499
p_int: 0.934882444
p_ni: 0.065117555
p_wrong: 1e-9
Score: 0.281
Data Source: BioPlex,STRINGDB
DYSF
Tbio
Novelty: 0.00248634
Score: 0.738
Data Source: STRINGDB
TSG101
Tbio
Novelty: 0.00211746
Score: 0.668
Data Source: STRINGDB
GP2
Tbio
Novelty: 0.00126542
Score: 0.651
Data Source: STRINGDB
CD63
Tchem
Novelty: 0.00072515
Score: 0.649
Data Source: STRINGDB
CD81
Tchem
Novelty: 0.00111328
Score: 0.645
Data Source: STRINGDB
SNRNP27
Tbio
Novelty: 0.0175187
Score: 0.638
Data Source: STRINGDB
CD9
Tbio
Novelty: 0.00095308
Score: 0.634
Data Source: STRINGDB
AHNAK
Tbio
Novelty: 0.01201996
Score: 0.632
Data Source: STRINGDB
FDPS
Tclin
Family: Enzyme
Novelty: 0.00164195
Score: 0.621
Data Source: STRINGDB
Publication Statistics
PubMed Score  431.37

PubMed score by year
PubTator Score  105.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer