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Tbio
IRF2
Interferon regulatory factor 2

Protein Summary
Description
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393593
  • ENSP00000377218
  • ENSG00000168310

Symbol
  • IRF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.93
transcription factor binding site profile
0.93
histone modification site profile
0.77
virus perturbation
0.76
PubMedID
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.25   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 467   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.25   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 467   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
1
1
65
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
65
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
interferon regulatory factor 2
694347
Mouse
MGI:96591
16363
Rat
RGD:1304922
290749
Dog
interferon regulatory factor 2
VGNC:42092
475633
Horse
interferon regulatory factor 2
VGNC:19131
100050990
Species
Name
OMA
EggNOG
Inparanoid
Macaque
interferon regulatory factor 2
Mouse
Rat
Dog
interferon regulatory factor 2
Horse
interferon regulatory factor 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P14316-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Reactome
Interferon Signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Interferon Signaling
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (264)
1 – 10 of 264
IRF2BPL
Tdark
Novelty: 0.05458595
p_int: 0.999999893
p_ni: 1.07e-7
Score: 0.897
Data Source: BioPlex,STRINGDB
FAM208B
Tdark
Novelty: 1.21420488
p_int: 0.999995182
p_ni: 0.000004818
Score: 0.243
Data Source: BioPlex,STRINGDB
CTSS
Tchem
Family: Enzyme
Novelty: 0.00786042
p_int: 0.999995019
p_wrong: 0.000004981
Score: 0.59
Data Source: BioPlex,STRINGDB
IRF2BP2
Tbio
Novelty: 0.06703794
p_int: 0.999979274
p_ni: 0.000020726
Score: 0.928
Data Source: BioPlex,STRINGDB
IRF2BP1
Tdark
Novelty: 0.29719488
p_int: 0.9999741
p_ni: 0.000025899
p_wrong: 1e-9
Score: 0.972
Data Source: BioPlex,STRINGDB
FOXK2
Tbio
Family: TF
Novelty: 0.01420141
p_int: 0.999787026
p_ni: 0.000212974
Score: 0.57
Data Source: BioPlex,STRINGDB
FOXK1
Tbio
Family: TF
Novelty: 0.01321144
p_int: 0.995606935
p_ni: 0.004393065
Score: 0.239
Data Source: BioPlex,STRINGDB
HCFC2
Tbio
Novelty: 0.12260416
p_int: 0.874305899
p_ni: 0.125694101
Score: 0.196
Data Source: BioPlex,STRINGDB
IFNB1
Tbio
Novelty: 0.00011797
Score: 0.971
Data Source: STRINGDB
STAT2
Tbio
Family: TF
Novelty: 0.00241454
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score  185.25

PubMed score by year
PubTator Score  134.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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