You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SPATA7
Spermatogenesis-associated protein 7

Protein Summary
Description
Involved in photoreceptor cells maintenance (By similarity). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as protein trafficking across the CC to the outer segments (By similarity). This gene, originally isolated from testis, is also expressed in retina. Mutations in this gene are associated with Leber congenital amaurosis and juvenile retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000045347
  • ENSP00000045347
  • ENSG00000042317
  • ENST00000356583
  • ENSP00000348991
  • ENST00000393545
  • ENSP00000377176
  • ENST00000556553
  • ENSP00000451128

Symbol
  • HSD3
  • HSD3
  • LCA3
  • HSD-3.1
  • HEL-S-296
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
cell line
0.67
transcription factor perturbation
0.61
cell type or tissue
0.59
cellular component
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.27   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.27   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (12)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (76)
1 – 10 of 76
LCA5
Tbio
Novelty: 0.0379066
Score: 0.832
Data Source: STRINGDB
RD3
Tbio
Novelty: 0.00651981
Score: 0.826
Data Source: STRINGDB
TULP1
Tbio
Family: TF
Novelty: 0.0192093
Score: 0.811
Data Source: STRINGDB
RDH12
Tbio
Family: Enzyme
Novelty: 0.016003
Score: 0.78
Data Source: STRINGDB
CRB1
Tbio
Novelty: 0.00560299
Score: 0.759
Data Source: STRINGDB
AIPL1
Tbio
Novelty: 0.01436649
Score: 0.754
Data Source: STRINGDB
CEP290
Tbio
Novelty: 0.00526375
Score: 0.742
Data Source: STRINGDB
TTC8
Tbio
Novelty: 0.08520636
Score: 0.738
Data Source: STRINGDB
NEK4
Tbio
Family: Kinase
Novelty: 0.05805595
Score: 0.729
Data Source: STRINGDB
IQCB1
Tbio
Novelty: 0.02979098
Score: 0.716
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.27

PubMed score by year
PubTator Score  20.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer