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Tdark
RGL3
Ral guanine nucleotide dissociation stimulator-like 3

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393423
  • ENSP00000377075
  • ENSG00000205517
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.84
transcription factor
0.59
tissue sample
0.53
cell type or tissue
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.51   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.51   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
81.2
3
1
1
7.8
78.7
Agents acting on the renin-angiotensin system use measurement
1
1
1
47
Calcium channel blocker use measurement
1
1
1
40.9
Diuretic use measurement
1
1
1
32.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
81.2
1
7.8
78.7
Agents acting on the renin-angiotensin system use measurement
1
47
Calcium channel blocker use measurement
1
40.9
Diuretic use measurement
1
32.6
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (17)
1 – 10 of 17
RIT1
Tbio
Family: Enzyme
Novelty: 0.02780594
Score: 0.806
Data Source: STRINGDB
RALA
Tbio
Family: Enzyme
Novelty: 0.00257914
Score: 0.686
Data Source: STRINGDB
RALB
Tbio
Family: Enzyme
Novelty: 0.01605746
Score: 0.669
Data Source: STRINGDB
FAM200A
Tdark
Novelty: 1.44999522
Score: 0.539
Data Source: STRINGDB
MRAS
Tbio
Family: Enzyme
Novelty: 0.01544981
Score: 0.491
Data Source: STRINGDB
ZBP1
Tbio
Novelty: 0.01316413
Score: 0.487
Data Source: STRINGDB
RRAS
Tbio
Family: Enzyme
Novelty: 0.00786502
Score: 0.484
Data Source: STRINGDB
PLEKHJ1
Tdark
Novelty: 1.44399298
Score: 0.474
Data Source: STRINGDB
MGST3
Tbio
Family: Enzyme
Novelty: 0.02891864
Score: 0.449
Data Source: STRINGDB
SCRN3
Tbio
Family: Enzyme
Novelty: 0.03516382
Score: 0.443
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.51

PubMed score by year
PubTator Score  3.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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