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Tbio
BANP
Protein BANP

Protein Summary
Description
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity). This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286122
  • ENSP00000286122
  • ENSG00000172530
  • ENST00000355022
  • ENSP00000347125
  • ENST00000393207
  • ENSP00000376902
  • ENST00000393208
  • ENSP00000376903
  • ENST00000479780
  • ENSP00000432508
  • ENST00000538234
  • ENSP00000444352
  • ENST00000626016
  • ENSP00000487304

Symbol
  • BEND1
  • SMAR1
  • BEND1
  • SMAR1
  • SMARBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor binding site profile
0.97
transcription factor
0.79
cell type or tissue
0.77
tissue sample
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.61   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.61   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
1
6
97
testosterone measurement
2
2
2
91.5
high density lipoprotein cholesterol measurement
1
1
1
41.7
systolic blood pressure
1
1
1
36.2
apolipoprotein A 1 measurement
1
1
1
28.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
97
testosterone measurement
2
91.5
high density lipoprotein cholesterol measurement
1
41.7
systolic blood pressure
1
36.2
apolipoprotein A 1 measurement
1
28.8
Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Activity through Association with Co-factors
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Activity through Association with Co-factors
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (68)
1 – 10 of 68
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.999999516
p_ni: 4.83e-7
p_wrong: 1e-9
Data Source: BioPlex
VMAC
Tdark
Novelty: 0.83333333
p_int: 0.999985686
p_ni: 0.00001431
p_wrong: 4e-9
Score: 0.252
Data Source: BioPlex,STRINGDB
FAM9C
Tdark
Novelty: 0.86727989
p_int: 0.99997829
p_ni: 0.00002171
Data Source: BioPlex
WASHC3
Tdark
Novelty: 0.18307321
p_int: 0.999976603
p_ni: 0.000023396
Data Source: BioPlex
NGRN
Tbio
Novelty: 0.11162143
p_int: 0.999967463
p_ni: 0.000032537
Data Source: BioPlex
TROAP
Tbio
Novelty: 0.06268103
p_int: 0.999638942
p_ni: 0.000358081
p_wrong: 0.000002978
Data Source: BioPlex
HEXIM2
Tbio
Novelty: 0.14814693
p_int: 0.999503702
p_ni: 0.000496265
p_wrong: 3.3e-8
Score: 0.206
Data Source: BioPlex,STRINGDB
PDHB
Tbio
Family: Enzyme
Novelty: 0.01018086
p_int: 0.999364756
p_ni: 0.000634348
p_wrong: 8.96e-7
Data Source: BioPlex
MATN2
Tbio
Novelty: 0.08506252
p_int: 0.999349474
p_ni: 0.000650525
Data Source: BioPlex
CPSF4L
Tdark
Novelty: 4.27116708
p_int: 0.997940961
p_ni: 0.00205901
p_wrong: 2.9e-8
Score: 0.222
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  56.61

PubMed score by year
PubTator Score  22.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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