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Tbio
IL36RN
Interleukin-36 receptor antagonist protein

Protein Summary
Description
Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346807
  • ENSP00000259212
  • ENSG00000136695
  • ENST00000393200
  • ENSP00000376896

Symbol
  • FIL1D
  • IL1F5
  • IL1HY1
  • IL1L1
  • IL1RP3
  • FIL1
  • FIL1D
  • IL1F5
  • IL1L1
  • PSORP
  • IL1HY1
  • IL1RP3
  • IL36RA
  • IL-36Ra
  • PSORS14
  • FIL1(DELTA)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
protein domain
0.73
tissue
0.64
virus perturbation
0.59
molecular function
0.56


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.31   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.31   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1859325
54450
Rat
RGD:1311212
311783
Dog
interleukin 36 receptor antagonist
VGNC:41985
611869
Horse
interleukin 36 receptor antagonist
VGNC:19032
100065154
Cow
interleukin 36 receptor antagonist
VGNC:30159
518514
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
interleukin 36 receptor antagonist
Horse
interleukin 36 receptor antagonist
Cow
interleukin 36 receptor antagonist
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UBH0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-36 pathway
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-36 pathway
Signaling by Interleukins
Protein-Protein Interactions (93)
1 – 10 of 93
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.999854091
p_ni: 0.000093092
p_wrong: 0.000052817
Data Source: BioPlex
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.998068002
p_ni: 0.001855021
p_wrong: 0.000076977
Data Source: BioPlex
RRAS
Tbio
Family: Enzyme
Novelty: 0.00786502
p_int: 0.994988362
p_ni: 0.004748841
p_wrong: 0.000262797
Data Source: BioPlex
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
p_int: 0.987846331
p_ni: 0.012153151
p_wrong: 5.18e-7
Score: 0.315
Data Source: BioPlex,STRINGDB
UBB
Tbio
Novelty: 0.00661254
p_int: 0.987684935
p_ni: 0.012315065
Data Source: BioPlex
SRSF8
Tdark
Novelty: 0.16509556
p_int: 0.968763036
p_ni: 0.003556798
p_wrong: 0.027680166
Score: 0.167
Data Source: BioPlex,STRINGDB
HNRNPLL
Tbio
Novelty: 0.0498467
p_int: 0.918945336
p_ni: 0.074545822
p_wrong: 0.006508842
Data Source: BioPlex
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.852566531
p_ni: 0.00013157
p_wrong: 0.1473019
Data Source: BioPlex
IL36B
Tbio
Novelty: 0.05952789
Score: 0.993
Data Source: STRINGDB
IL1RL2
Tbio
Novelty: 0.0156461
Score: 0.991
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  160.31

PubMed score by year
PubTator Score  90.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer