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Tbio
VWA2
von Willebrand factor A domain-containing protein 2

Protein Classes
Protein Summary
Description
This gene encodes a member of the von Willebrand factor A-like domain protein superfamily. The encoded protein is localized to the extracellular matrix and may serve as a structural component in basement membranes or in anchoring structures on scaffolds of collagen VII or fibrillin. This gene has been linked to type 1A diabetes and is a candidate serological marker for colon cancer. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392982
  • ENSP00000376708
  • ENSG00000165816
  • ENST00000603594
  • ENSP00000473752

Symbol
  • AMACO
  • AMACO
  • CCSP2
  • NET42
  • CCSP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
PubMedID
0.57
tissue sample
0.52
cell line
0.49
cell type or tissue
0.48


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.5   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.5   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
von Willebrand factor A domain containing 2
698261
Mouse
MGI:2684334
240675
Rat
RGD:1562000
307988
Dog
von Willebrand factor A domain containing 2
VGNC:48319
477827
Horse
von Willebrand factor A domain containing 2
VGNC:24951
100068127
Species
Name
OMA
EggNOG
Inparanoid
Macaque
von Willebrand factor A domain containing 2
Mouse
Rat
Dog
von Willebrand factor A domain containing 2
Horse
von Willebrand factor A domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5GFL6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (27)
1 – 10 of 27
TCTEX1D2
Tbio
Novelty: 0.15075459
p_int: 0.999193671
p_ni: 0.00004613
p_wrong: 0.0007602
Score: 0.203
Data Source: BioPlex,STRINGDB
UBB
Tbio
Novelty: 0.00661254
p_int: 0.995485145
p_ni: 0.004514855
Score: 0.224
Data Source: BioPlex,STRINGDB
KLF15
Tbio
Family: TF
Novelty: 0.009709
p_int: 0.994392347
p_ni: 0.005607643
p_wrong: 1.1e-8
Score: 0.269
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.961488997
p_ni: 0.038511003
Data Source: BioPlex
WDR47
Tdark
Novelty: 0.51632776
p_int: 0.933761195
p_ni: 0.066084918
p_wrong: 0.000153887
Score: 0.239
Data Source: BioPlex,STRINGDB
HSPA2
Tbio
Novelty: 0.01696667
p_int: 0.841105174
p_ni: 0.158894826
Score: 0.553
Data Source: BioPlex,STRINGDB
NHLRC2
Tbio
Novelty: 0.18676651
Score: 0.757
Data Source: STRINGDB
FREM2
Tbio
Novelty: 0.03382033
Score: 0.733
Data Source: STRINGDB
FRAS1
Tbio
Novelty: 0.02114063
Score: 0.688
Data Source: STRINGDB
FREM3
Tdark
Novelty: 0.16573809
Score: 0.601
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.50

PubMed score by year
PubTator Score  5.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer