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Tbio
SYCP3
Synaptonemal complex protein 3

Protein Summary
Description
Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility (PubMed:14643120). Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity). This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266743
  • ENSP00000266743
  • ENSG00000139351
  • ENST00000392924
  • ENSP00000376655
  • ENST00000392927
  • ENSP00000376658

Symbol
  • SCP3
  • COR1
  • SCP3
  • SPGF4
  • RPRGL4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
cell type or tissue
0.62
tissue sample
0.56
PubMedID
0.54
cell line
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.45   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.45   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic synapsis
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic synapsis
Reproduction
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (128)
1 – 10 of 128
BLK
Tchem
Family: Kinase
Novelty: 0.00480349
p_int: 0.98493422
p_ni: 0.000251087
p_wrong: 0.014814692
Score: 0.517
Data Source: BioPlex,STRINGDB
SYCP2
Tbio
Novelty: 0.05040533
Score: 0.993
Data Source: Reactome,STRINGDB
SYCP1
Tbio
Novelty: 0.01493554
Score: 0.992
Data Source: STRINGDB
REC8
Tbio
Novelty: 0.00732742
Score: 0.984
Data Source: STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
Score: 0.975
Data Source: Reactome,STRINGDB
STAG3
Tbio
Novelty: 0.03329703
Score: 0.973
Data Source: STRINGDB
TEX12
Tbio
Novelty: 0.11828137
Score: 0.973
Data Source: STRINGDB
SYCE2
Tbio
Novelty: 0.16889301
Score: 0.972
Data Source: STRINGDB
SYCE1
Tbio
Novelty: 0.05038876
Score: 0.97
Data Source: STRINGDB
SMC3
Tbio
Novelty: 0.00474377
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  221.45

PubMed score by year
PubTator Score  115.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer