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Tdark
NT5DC3
5'-nucleotidase domain-containing protein 3

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392876
  • ENSP00000376615
  • ENSG00000111696

Symbol
  • GNN
  • TU12B1-TY
  • TU12B1TY
  • TU12B1-TY
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
disease perturbation
0.83
histone modification site profile
0.78
small molecule perturbation
0.77
kinase perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.95   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.95   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
1
1
0
8.4
27.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
8.4
27.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5'-nucleotidase domain containing 3
VGNC:5509
467110
Macaque
5'-nucleotidase domain containing 3
699285
Mouse
MGI:3513266
103466
Rat
RGD:1593358
691922
Dog
5'-nucleotidase domain containing 3
VGNC:43999
612224
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5'-nucleotidase domain containing 3
Macaque
5'-nucleotidase domain containing 3
Mouse
Rat
Dog
5'-nucleotidase domain containing 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q86UY8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (38)
1 – 10 of 38
ZNF211
Tdark
Family: TF
Novelty: 1.09151646
p_int: 0.959761923
p_ni: 0.040237913
p_wrong: 1.64e-7
Score: 0.403
Data Source: BioPlex,STRINGDB
NT5DC2
Tbio
Family: Enzyme
Novelty: 0.18487271
p_int: 0.858307407
p_ni: 0.141692593
Score: 0.492
Data Source: BioPlex,STRINGDB
HCFC2
Tbio
Novelty: 0.12260416
Score: 0.774
Data Source: STRINGDB
TNN
Tbio
Novelty: 0.02801297
Score: 0.733
Data Source: STRINGDB
ZKSCAN7
Tbio
Family: TF
Novelty: 0.00670558
Score: 0.669
Data Source: STRINGDB
RIOX2
Tbio
Family: Epigenetic
Novelty: 0.03254245
Score: 0.645
Data Source: STRINGDB
HSPB3
Tbio
Novelty: 0.00078884
Score: 0.634
Data Source: STRINGDB
GABRR3
Tbio
Family: IC
Novelty: 0.01890426
Score: 0.63
Data Source: STRINGDB
FLT1
Tclin
Family: Kinase
Novelty: 0.00039648
Score: 0.62
Data Source: STRINGDB
SYN3
Tbio
Novelty: 0.0065245
Score: 0.6
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.95

PubMed score by year
PubTator Score  1.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer