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Tbio
RIC8B
Synembryn-B

Protein Summary
Description
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355478
  • ENSP00000347662
  • ENSG00000111785
  • ENST00000392839
  • ENSP00000376583
  • ENST00000462949
  • ENSP00000435301
  • ENST00000470960
  • ENSP00000436359
  • ENST00000638198
  • ENSP00000492690

Symbol
  • RIC8
  • hSyn
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
histone modification site profile
0.86
cell type or tissue
0.76
microRNA
0.69
tissue
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.09   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.09   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
3
3
85.2
BMI-adjusted waist-hip ratio
1
1
1
76.3
testosterone measurement
1
1
1
67.7
cup-to-disc ratio measurement
2
2
2
66.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
85.2
BMI-adjusted waist-hip ratio
1
76.3
testosterone measurement
1
67.7
cup-to-disc ratio measurement
2
66.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RIC8 guanine nucleotide exchange factor B
VGNC:5570
452203
Macaque
RIC8 guanine nucleotide exchange factor B
703061
Mouse
MGI:2682307
237422
Rat
RGD:631419
314681
Dog
RIC8 guanine nucleotide exchange factor B
VGNC:45573
481294
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RIC8 guanine nucleotide exchange factor B
Macaque
RIC8 guanine nucleotide exchange factor B
Mouse
Rat
Dog
RIC8 guanine nucleotide exchange factor B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NVN3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (81)
1 – 10 of 81
MAGED2
Tbio
Novelty: 0.0134998
p_int: 0.99923332
p_ni: 0.00076668
Score: 0.806
Data Source: BioPlex,STRINGDB
ABHD8
Tdark
Family: Enzyme
Novelty: 0.27752967
p_int: 0.93560692
p_ni: 0.06439308
Data Source: BioPlex
NAP1L1
Tbio
Novelty: 0.03895314
p_int: 0.924522669
p_ni: 0.075477331
Score: 0.787
Data Source: BioPlex,STRINGDB
UBE2O
Tbio
Novelty: 0.07084123
p_int: 0.917514803
p_ni: 0.082485174
p_wrong: 2.2e-8
Score: 0.165
Data Source: BioPlex,STRINGDB
INTU
Tbio
Novelty: 0.02714388
p_int: 0.895299765
p_ni: 0.104700234
p_wrong: 1e-9
Score: 0.175
Data Source: BioPlex,STRINGDB
ENSA
Tbio
Novelty: 0.01642444
p_int: 0.88935298
p_ni: 0.107837549
p_wrong: 0.002809471
Score: 0.169
Data Source: BioPlex,STRINGDB
TIGD5
Tdark
Novelty: 1.93340494
p_int: 0.885411824
p_ni: 0.110834885
p_wrong: 0.003753292
Data Source: BioPlex
AARSD1
Tdark
Novelty: 0.75372406
p_int: 0.827002326
p_ni: 0.172997666
p_wrong: 7e-9
Data Source: BioPlex
GNAS
Tbio
Novelty: 0.00284739
p_int: 0.817472827
p_ni: 0.182527173
Score: 0.869
Data Source: BioPlex,STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.949
Data Source: STRINGDB
Publication Statistics
PubMed Score  233.09

PubMed score by year
PubTator Score  9.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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