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Tbio
SCN3B
Sodium channel subunit beta-3

Protein Summary
Description
Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299333
  • ENSP00000299333
  • ENSG00000166257
  • ENST00000392770
  • ENSP00000376523
  • ENST00000530277
  • ENSP00000432785

Symbol
  • KIAA1158
  • SCNB3
  • ATFB16
  • BRGDA7
  • HSA243396
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
molecular function
0.91
protein domain
0.85
histone modification site profile
0.73
biological process
0.71


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.6   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.6   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sodium voltage-gated channel beta subunit 3
VGNC:7497
466810
Macaque
sodium voltage-gated channel beta subunit 3
714673
Mouse
MGI:1918882
235281
Rat
RGD:621657
245956
Dog
sodium voltage-gated channel beta subunit 3
VGNC:45919
610239
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sodium voltage-gated channel beta subunit 3
Macaque
sodium voltage-gated channel beta subunit 3
Mouse
Rat
Dog
sodium voltage-gated channel beta subunit 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NY72-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
Gene Ontology Terms (29)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (169)
1 – 10 of 169
SOGA3
Tdark
Novelty: 2.17187131
p_int: 0.999999973
p_ni: 2.1e-8
p_wrong: 7e-9
Score: 0.184
Data Source: BioPlex,STRINGDB
DHRS7
Tbio
Family: Enzyme
Novelty: 0.16713756
p_int: 0.999999407
p_ni: 5.93e-7
Data Source: BioPlex
TARBP1
Tbio
Family: Enzyme
Novelty: 0.04886897
p_int: 0.999974608
p_ni: 0.000025392
Data Source: BioPlex
DPY19L1
Tdark
Family: Enzyme
Novelty: 0.34765717
p_int: 0.999934093
p_ni: 0.000065907
Data Source: BioPlex
CENPL
Tdark
Novelty: 0.18429095
p_int: 0.999927726
p_ni: 0.000072274
Data Source: BioPlex
UTP20
Tbio
Novelty: 0.09170451
p_int: 0.999913449
p_ni: 0.000086551
Data Source: BioPlex
CENPN
Tbio
Novelty: 0.06923443
p_int: 0.999906591
p_ni: 0.00009303
p_wrong: 3.79e-7
Data Source: BioPlex
ABCC5
Tchem
Family: Transporter
Novelty: 0.00566605
p_int: 0.999744971
p_ni: 0.000025685
p_wrong: 0.000229344
Score: 0.169
Data Source: BioPlex,STRINGDB
BCAP29
Tbio
Novelty: 0.09095623
p_int: 0.999593829
p_ni: 0.000002984
p_wrong: 0.000403186
Score: 0.169
Data Source: BioPlex,STRINGDB
TMTC4
Tdark
Novelty: 0.53734704
p_int: 0.9994683
p_ni: 0.000531699
p_wrong: 1e-9
Score: 0.243
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  19.60

PubMed score by year
PubTator Score  9.53

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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