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Tbio
PRKAR1A
cAMP-dependent protein kinase type I-alpha regulatory subunit

Protein Summary
Description
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358598
  • ENSP00000351410
  • ENSG00000108946
  • ENST00000392711
  • ENSP00000376475
  • ENST00000536854
  • ENSP00000445625
  • ENST00000586397
  • ENSP00000466459
  • ENST00000588188
  • ENSP00000468106
  • ENST00000589228
  • ENSP00000464977

Symbol
  • PKR1
  • PRKAR1
  • TSE1
  • CAR
  • CNC
  • CNC1
  • PKR1
  • TSE1
  • ADOHR
  • PPNAD1
  • PRKAR1
  • ACRDYS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
biological process
0.99
molecular function
0.97
disease perturbation
0.93
hub protein
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.35   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.35   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
16.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
16.7
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (66)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Aquaporin-mediated transport
Reactome
CREB1 phosphorylation through the activation of Adenylate Cyclase
Reactome
Ca-dependent events
Reactome
CaM pathway
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Aquaporin-mediated transport
CREB1 phosphorylation through the activation of Adenylate Cyclase
Ca-dependent events
CaM pathway
Gene Ontology Terms (31)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (198)
1 – 10 of 198
AKAP3
Tbio
Family: Enzyme
Novelty: 0.030936
p_int: 0.999999997
p_wrong: 3e-9
Score: 0.579
Data Source: BioPlex,STRINGDB
PRKACB
Tchem
Family: Kinase
Novelty: 0.01962222
p_int: 0.999999993
p_ni: 7e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
GPR161
Tbio
Family: GPCR
Novelty: 0.00235739
p_int: 0.999999973
p_ni: 2.7e-8
Score: 0.981
Data Source: BioPlex,STRINGDB
PRKAR1B
Tbio
Family: Enzyme
Novelty: 0.05355517
p_int: 0.999998904
p_ni: 0.000001086
p_wrong: 1e-8
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
PRKACG
Tbio
Family: Kinase
Novelty: 0.11080061
p_int: 0.999998219
p_ni: 0.000001781
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
ANKRD26
Tbio
Novelty: 0.02266046
p_int: 0.999962046
p_ni: 0.000037945
p_wrong: 1e-8
Score: 0.548
Data Source: BioPlex,STRINGDB
AKAP11
Tbio
Family: Enzyme
Novelty: 0.0685826
p_int: 0.999585479
p_ni: 0.000414521
Score: 0.772
Data Source: BioPlex,STRINGDB
PRKACA
Tchem
Family: Kinase
Novelty: 0.03869658
p_int: 0.990792758
p_ni: 0.009207239
p_wrong: 3e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
STOML2
Tbio
Novelty: 0.07828354
p_int: 0.97291273
p_ni: 0.02708727
Score: 0.545
Data Source: BioPlex,STRINGDB
ZBED1
Tbio
Family: TF
Novelty: 0.01645222
p_int: 0.952918487
p_ni: 0.04705291
p_wrong: 0.000028602
Score: 0.21
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  363.35

PubMed score by year
PubTator Score  288.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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