You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
SDK2
Protein sidekick-2

Protein Summary
Description
Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392650
  • ENSP00000376421
  • ENSG00000069188

Symbol
  • KIAA1514
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
microRNA
0.72
transcription factor binding site profile
0.63
tissue sample
0.62
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.79   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 17   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.79   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
SDK interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
SDK interactions
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (52)
1 – 10 of 52
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.999998879
p_ni: 0.00000112
Data Source: BioPlex
CLU
Tbio
Novelty: 0.00054776
p_int: 0.999979449
p_ni: 0.000020551
Score: 0.202
Data Source: BioPlex,STRINGDB
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.999929598
p_ni: 0.000069762
p_wrong: 6.39e-7
Data Source: BioPlex
PCDHGB1
Tdark
Novelty: 0.60440805
p_int: 0.999809605
p_ni: 0.000189789
p_wrong: 6.06e-7
Score: 0.18
Data Source: BioPlex,STRINGDB
SIGLECL1
Tdark
p_int: 0.999542054
p_ni: 0.000456614
p_wrong: 0.000001332
Data Source: BioPlex
CEACAM21
Tdark
Novelty: 0.46116153
p_int: 0.996454207
p_ni: 0.002671434
p_wrong: 0.000874359
Data Source: BioPlex
RAET1E
Tbio
Novelty: 0.01859274
p_int: 0.995825013
p_ni: 0.003708595
p_wrong: 0.000466391
Score: 0.179
Data Source: BioPlex,STRINGDB
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.994568512
p_ni: 0.005431487
Data Source: BioPlex
ADAM17
Tchem
Family: Enzyme
Novelty: 0.00121971
p_int: 0.992623704
p_ni: 0.00561797
p_wrong: 0.001758326
Score: 0.232
Data Source: BioPlex,STRINGDB
FAM19A5
Tdark
Novelty: 0.07792418
p_int: 0.989830516
p_ni: 0.010169483
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  10.79

PubMed score by year
PubTator Score  3.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer